糖皮质激素治疗 COVID-19。
Glucocorticoid Therapy in COVID-19.
机构信息
Respiratory Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
出版信息
Semin Respir Crit Care Med. 2023 Feb;44(1):100-117. doi: 10.1055/s-0042-1759778. Epub 2023 Jan 16.
Abstract
Coronavirus disease 2019 (COVID-19) pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant mortality in pandemic proportions. Inflammation in response to the infection contributes to the pathogenesis of pneumonia. This review will discuss prior studies on the use of glucocorticoids to treat respiratory infections, the rationale for the use glucocorticoids in COVID-19, and review of existing data. We will also highlight outstanding research questions for future studies.
摘要
新型冠状病毒病（COVID-19）肺炎是由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起的，在大流行中导致了极高的死亡率。感染引起的炎症导致肺炎的发病机制。这篇综述将讨论先前关于使用糖皮质激素治疗呼吸道感染的研究，使用糖皮质激素治疗 COVID-19 的基本原理，并回顾现有数据。我们还将突出未来研究的悬而未决的问题。
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