Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA.
Department of Psychology, Wayne State University, Detroit, MI, USA.
Nat Commun. 2023 Jan 16;14(1):230. doi: 10.1038/s41467-022-35742-z.
Puberty is an important developmental period marked by hormonal, metabolic and immune changes. Puberty also marks a shift in sex differences in susceptibility to asthma. Yet, little is known about the gene expression changes in immune cells that occur during pubertal development. Here we assess pubertal development and leukocyte gene expression in a longitudinal cohort of 251 children with asthma. We identify substantial gene expression changes associated with age and pubertal development. Gene expression changes between pre- and post-menarcheal females suggest a shift from predominantly innate to adaptive immunity. We show that genetic effects on gene expression change dynamically during pubertal development. Gene expression changes during puberty are correlated with gene expression changes associated with asthma and may explain sex differences in prevalence. Our results show that molecular data used to study the genetics of early onset diseases should consider pubertal development as an important factor that modifies the transcriptome.
青春期是一个重要的发育阶段，其特点是激素、代谢和免疫变化。青春期也标志着哮喘易感性的性别差异发生转变。然而，人们对发生在青春期发育过程中的免疫细胞中的基因表达变化知之甚少。在这里，我们评估了 251 名哮喘儿童的纵向队列中的青春期发育和白细胞基因表达情况。我们确定了与年龄和青春期发育相关的大量基因表达变化。处于月经初潮前和月经初潮后的女性之间的基因表达变化表明，从主要的先天免疫向适应性免疫的转变。我们表明，在青春期发育过程中，遗传对基因表达的影响是动态变化的。青春期的基因表达变化与与哮喘相关的基因表达变化相关，可能解释了患病率的性别差异。我们的研究结果表明，用于研究早发性疾病遗传学的分子数据应将青春期发育视为改变转录组的重要因素。
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