评估黎巴嫩人群的亚群结构：使用 23 个常染色体短串联重复序列数据的人群研究。
Assessing population substructure in the Lebanese population: A population study using data on 23 autosomal short tandem repeats.
机构信息
Molecular Biology Laboratory, Faculty of Health Sciences, American University of Science and Technology, Beirut, Lebanon.
School of Criminal Justice, University of Lausanne, Lausanne, Switzerland.
出版信息
Mol Genet Genomic Med. 2023 Apr;11(4):e2118. doi: 10.1002/mgg3.2118. Epub 2023 Jan 19.
BACKGROUND
Understanding the genetic substructure of a population is essential for proper forensic genetic analysis. The Lebanese population has a high rate of endogamous and consanguineous marriages and is segregated based on religious belongings. However, no genetic population studies have been performed up to date to estimate the degree of genetic substructure and inbreeding coefficients.
METHODS
The present study analyzed a compendium of 23 autosomal STRs typed in 1400 individuals belonging to the seven major Lebanese religious subcommunities. Inbreeding coefficients such as F statistics were estimated.
RESULTS
Results showed a Fst (theta) value of 0.002, indicating a low genetic subdivision within the Lebanese population.
CONCLUSION
This study aimed at assessing the genetic substructure of the Lebanese population by analyzing 1400 Lebanese citizens' samples using 23 STR markers. F statistics were computed to evaluate the degree of genetic substructure. Results showed a Fst value of 0.002, indicating a low genetic subdivision within the Lebanese population.
背景
了解人群的遗传亚结构对于正确的法医遗传学分析至关重要。黎巴嫩人口中存在着较高的近亲结婚和血缘婚姻的比例，并且根据宗教信仰进行隔离。然而，迄今为止，还没有进行任何遗传群体研究来估计遗传亚结构和近交系数的程度。
方法
本研究分析了属于黎巴嫩七个主要宗教群体的 1400 个人的 23 个常染色体 STR 基因座的数据。估计了 F 统计量等近交系数。
结果
结果显示 Fst（theta）值为 0.002，表明黎巴嫩人群内的遗传亚结构较低。
结论
本研究旨在通过分析 1400 名黎巴嫩公民的样本，使用 23 个 STR 标记来评估黎巴嫩人口的遗传亚结构。计算 F 统计量以评估遗传亚结构的程度。结果显示 Fst 值为 0.002，表明黎巴嫩人群内的遗传亚结构较低。
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