Lai Shian, Zhang Quan, Jin Lin
Small Molecule Drugs Sichuan Key Laboratory, Institute of Materia Medica, School of Pharmacy, Chengdu Medical College, Chengdu 610500, China.
Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, Kyotanabe 610-0394, Japan.
Antibiotics (Basel). 2022 Dec 27;12(1):42. doi: 10.3390/antibiotics12010042.
In recent years, an increasing number of drug-resistant bacterial strains have been identified due to the abuse of antibiotics, which seriously threatens human and animal health. Antimicrobial peptides (AMPs) have become one of the most effective weapons to solve this problem. AMPs have little tendency to induce drug resistance and have outstanding antimicrobial effects. The study of AMPs, especially cyclic peptides, has become a hot topic. Among them, macrocyclic AMPs have received extensive attention. This mini-review discusses the structures and functions of the dominant cyclic natural and synthetic AMPs and provides a little outlook on the future direction of cyclic AMPs.
近年来，由于抗生素的滥用，已鉴定出越来越多的耐药细菌菌株，这严重威胁着人类和动物的健康。抗菌肽（AMPs）已成为解决这一问题最有效的武器之一。抗菌肽几乎没有诱导耐药性的倾向，并且具有出色的抗菌效果。对抗菌肽，尤其是环肽的研究已成为一个热门话题。其中，大环抗菌肽受到了广泛关注。本综述讨论了主要的环状天然和合成抗菌肽的结构和功能，并对环状抗菌肽的未来发展方向作了简要展望。
