晶体储存性组织细胞增多症：更严重病症的冰山一角。

Crystal-Storing Histiocytosis: The Iceberg of More Serious Conditions.

作者信息

Mobarki Mousa, Papoudou-Bai Alexandra, Dumollard Jean Marc, Alhazmi Abdulaziz H, Musawi Shaqraa, Madkhali Mohammed Ali, Muqri Khalid Y, Péoc'h Michel, Karpathiou Georgia

机构信息

Pathology Department, Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia.

Pathology Department, Faculty of Medicine, University of Ioannina, 47100 Ioannina, Greece.

出版信息

Diagnostics (Basel). 2023 Jan 11;13(2):271. doi: 10.3390/diagnostics13020271.

DOI:10.3390/diagnostics13020271

PMID:36673081

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9858286/

Abstract

Crystal-storing histiocytosis is a rare condition that is histologically characterized by intracellular cytoplasmic crystalline inclusions. It usually presents monoclonal immunoglobulins that deposit within histiocytes, which accumulate and affect different organs of the human body and are commonly associated with lymphoproliferative conditions, especially those with plasmacytic differentiation. The prognosis of this condition is variable and related to the underlying clinical disease. In this review article, we aim to describe and discuss the clinical and pathological characteristics of crystal-storing histiocytosis based on the available literature and to provide a thorough differential diagnosis.

摘要

晶体贮积性组织细胞增多症是一种罕见疾病，其组织学特征为细胞内细胞质晶体包涵体。它通常表现为沉积在组织细胞内的单克隆免疫球蛋白，这些组织细胞会聚集并影响人体的不同器官，且通常与淋巴增殖性疾病相关，尤其是那些具有浆细胞分化的疾病。这种疾病的预后各不相同，与潜在的临床疾病有关。在这篇综述文章中，我们旨在根据现有文献描述和讨论晶体贮积性组织细胞增多症的临床和病理特征，并提供全面的鉴别诊断。