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青少年妊娠不良结局的流行病学:罗马尼亚东北部的一个三级转诊中心。

Epidemiology of Adverse Outcomes in Teenage Pregnancy-A Northeastern Romanian Tertiary Referral Center.

机构信息

Department of Obstetrics and Gynecology, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.

Department of Obstetrics and Gynecology, Cuza Vodă Hospital, 700038 Iasi, Romania.

出版信息

Int J Environ Res Public Health. 2023 Jan 10;20(2):1226. doi: 10.3390/ijerph20021226.

Abstract

Background: Despite being a very well-documented subject in the literature, there are still conflicting results regarding teenage pregnancies and their fetal outcomes. Methods: We conducted a retrospective, comparative cohort study that included 1082 mothers aged less than 18 years, compared to 41,998 mothers aged over 18 years, who delivered in our tertiary referral center between January 2015 and December 2021. To check for significant differences between the two groups, the chi-qquared or Fisher’s test for categorical variables were used. Results: We detected statistically significant higher rates of fetal malformation, premature birth, FGR and SGA fetal growth conditions, preeclampsia, condylomatosis and vaginal infection with E. coli in our cohort of teenagers. In this subpopulation of teenagers, the rate for premature birth at less than 32 weeks of gestation was 3.26-fold higher and 3.25-fold higher for condylomatosis, and these results referred to the cohort of adult patients (>18 years old) that gave birth in the same interval of time. Conclusions: Teenage pregnancies still remain a major health problem that burdens all countries worldwide regardless of their income. It needs solutions initially to prevent pregnancy in this young age segment and last but not least to improve both maternal and fetal outcomes.

摘要

背景

尽管在文献中已有充分的记载,但青少年妊娠及其胎儿结局仍存在相互矛盾的结果。

方法

我们进行了一项回顾性、比较队列研究,纳入了 1082 名年龄小于 18 岁的母亲,与 2015 年 1 月至 2021 年 12 月在我们的三级转诊中心分娩的 41998 名年龄大于 18 岁的母亲进行比较。为了检查两组之间的显著差异,我们使用卡方检验或 Fisher 检验进行了分类变量分析。

结果

我们在青少年组中发现胎儿畸形、早产、FGR 和 SGA 胎儿生长条件、子痫前期、尖锐湿疣和大肠杆菌阴道感染的发生率明显更高。在青少年这一亚群中,早产发生在 32 周之前的发生率是成年患者(>18 岁)的 3.26 倍,尖锐湿疣的发生率是成年患者的 3.25 倍,而这些结果是在同一时间段内出生的。

结论

青少年妊娠仍然是一个重大的健康问题,困扰着全世界所有国家,无论其收入水平如何。它需要最初的解决方案来预防这一年龄段的妊娠,最后但并非最不重要的是改善母婴结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1712/9859398/9037ba04d039/ijerph-20-01226-g001.jpg

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