Sandulovici Roxana Colette, Carmen-Marinela Mihailescu, Grigoroiu Alexandru, Moldovan Carmen Aura, Savin Mihaela, Ordeanu Viorel, Voicu Sorina Nicoleta, Cord Daniel, Costache Gabriela Mariana, Galatanu Mona Luciana, Popescu Mariana, Sarbu Iulian, Mati Erand, Ionescu Lucia Elena, Neagu Răzvan, Ţucureanu Vasilica, Claudia Rîmbu Mirela, Mihalache Iuliana, Romanitan Cosmin, Piperea-Sianu Alice, Boldeiu Adina, Brincoveanu Oana, Manea Carmen Elisabeta, Firtat Bogdan, Muscalu George Stelian, Dragomir David
Pharmacy Faculty, "Titu Maiorescu" University, 16 Sincai, 040314 Bucharest, Romania.
National Institute for Research and Development in Microtechnologies (IMT Bucharest), 126A Erou Iancu Nicolae Street, 72996 Bucharest, Romania.
Pharmaceuticals (Basel). 2022 Dec 29;16(1):48. doi: 10.3390/ph16010048.
Green chemistry is a pharmaceutical industry tool, which, when implemented correctly, can lead to a minimization in resource consumption and waste. An aqueous extract of L. was employed for the efficient and rapid synthesis of silver/gold particle nanostructures via an inexpensive, nontoxic and eco-friendly procedure. The nanoparticles were physicochemically characterized using ultraviolet-visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS), X-ray diffraction (XRD) and scanning electron microscopy (SEM), with the best stability of up to one year in the solution obtained for silver nanoparticles without any chemical additives. A comparison of the antimicrobial effect of silver/gold nanoparticles and their formulations (hydrogels, ointments, aqueous solutions) showed that both metallic nanoparticles have antibacterial and antibiofilm effects, with silver-based hydrogels having particularly high antibiofilm efficiency. The highest antibacterial and antibiofilm efficacies were obtained against when using silver nanoparticle hydrogels, with antibiofilm efficacies of over 75% registered. The hydrogels incorporating green nanoparticles displayed a 200% increased bacterial efficiency when compared to the controls and their components. All silver nanoparticle formulations were ecologically obtained by "green synthesis" and were shown to have an antimicrobial effect or potential as keratinocyte-acting pharmaceutical substances for ameliorating infectious psoriasis wounds.
绿色化学是制药行业的一种工具，若实施得当，可使资源消耗和废物产生降至最低。采用L.的水提取物，通过一种廉价、无毒且环保的方法高效快速地合成银/金颗粒纳米结构。使用紫外可见光谱（UV-Vis）、傅里叶变换红外光谱（FT-IR）、动态光散射（DLS）、X射线衍射（XRD）和扫描电子显微镜（SEM）对纳米颗粒进行了物理化学表征，在不添加任何化学添加剂的情况下，银纳米颗粒在溶液中的稳定性高达一年。对银/金纳米颗粒及其制剂（水凝胶、软膏、水溶液）的抗菌效果进行比较表明，两种金属纳米颗粒均具有抗菌和抗生物膜作用，其中银基水凝胶的抗生物膜效率特别高。使用银纳米颗粒水凝胶时，对[具体对象未给出]的抗菌和抗生物膜效果最佳，抗生物膜效率超过75%。与对照及其成分相比，掺入绿色纳米颗粒的水凝胶显示出细菌效率提高了200%。所有银纳米颗粒制剂均通过“绿色合成”生态获得，并显示出具有抗菌作用或作为用于改善感染性银屑病伤口的角质形成细胞作用药物物质的潜力。
