Ahmad Naveed
Department of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka 72388, Aljouf, Saudi Arabia.
Pharmaceutics. 2022 Dec 22;15(1):42. doi: 10.3390/pharmaceutics15010042.
Chronic wound management represents a major challenge in the healthcare sector owing to its delayed wound-healing process progression and huge financial burden. In this regard, wound dressings provide an appropriate platform for facilitating wound healing for several decades. However, adherent traditional wound dressings do not provide effective wound healing for highly exudating chronic wounds and need the development of newer and innovative wound dressings to facilitate accelerated wound healing. In addition, these dressings need frequent changing, resulting in more pain and discomfort. In order to overcome these issues, a wide range of affordable and innovative modern wound dressings have been developed and explored recently to accelerate and improve the wound healing process. However, a comprehensive understanding of various in vitro and in vivo characterization methods being utilized for the evaluation of different modern wound dressings is lacking. In this context, an overview of modern dressings and their complete in vitro and in vivo characterization methods for wound healing assessment is provided in this review. Herein, various emerging modern wound dressings with advantages and challenges have also been reviewed. Furthermore, different in vitro wound healing assays and in vivo wound models being utilized for the evaluation of wound healing progression and wound healing rate using wound dressings are discussed in detail. Finally, a summary of modern wound dressings with challenges and the future outlook is highlighted.
由于慢性伤口愈合过程延迟以及巨大的经济负担，慢性伤口管理成为医疗保健领域的一项重大挑战。在这方面，几十年来伤口敷料为促进伤口愈合提供了一个合适的平台。然而，粘性传统伤口敷料对于高渗出性慢性伤口并不能提供有效的伤口愈合效果，因此需要开发更新颖、创新的伤口敷料来促进伤口加速愈合。此外，这些敷料需要频繁更换，会带来更多疼痛和不适。为了克服这些问题，最近已经开发并探索了多种价格合理且创新的现代伤口敷料，以加速和改善伤口愈合过程。然而，目前缺乏对用于评估不同现代伤口敷料的各种体外和体内表征方法的全面了解。在此背景下，本综述提供了现代敷料及其用于伤口愈合评估的完整体外和体内表征方法的概述。本文还综述了各种具有优势和挑战的新兴现代伤口敷料。此外，还详细讨论了用于评估使用伤口敷料的伤口愈合进程和伤口愈合速率的不同体外伤口愈合试验和体内伤口模型。最后，强调了现代伤口敷料面临的挑战以及未来展望。
