Andrade Stéphanie, Nunes Débora, Dabur Meghna, Ramalho Maria J, Pereira Maria C, Loureiro Joana A
LEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.
ALiCE-Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.
Pharmaceutics. 2023 Jan 7;15(1):212. doi: 10.3390/pharmaceutics15010212.
Neurodegenerative diseases are caused by the gradual loss of neurons' function. These neurological illnesses remain incurable, and current medicines only alleviate the symptoms. Given the social and economic burden caused by the rising frequency of neurodegenerative diseases, there is an urgent need for the development of appropriate therapeutics. Natural compounds are gaining popularity as alternatives to synthetic drugs due to their neuroprotective properties and higher biocompatibility. While natural compounds' therapeutic effects for neurodegenerative disease treatment have been investigated in numerous in vitro and in vivo studies, only few have moved to clinical trials. This article provides the first systematic review of the clinical trials evaluating natural compounds' safety and efficacy for the treatment of the five most prevalent neurodegenerative disorders: Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease.
神经退行性疾病是由神经元功能的逐渐丧失引起的。这些神经系统疾病仍然无法治愈，目前的药物只能缓解症状。鉴于神经退行性疾病发病率上升所造成的社会和经济负担，迫切需要开发合适的治疗方法。天然化合物因其神经保护特性和更高的生物相容性，作为合成药物的替代品正越来越受欢迎。虽然在众多体外和体内研究中已经对天然化合物治疗神经退行性疾病的效果进行了研究，但只有少数进入了临床试验阶段。本文首次对评估天然化合物治疗五种最常见神经退行性疾病（阿尔茨海默病、帕金森病、多发性硬化症、肌萎缩侧索硬化症和亨廷顿舞蹈症）的安全性和有效性的临床试验进行了系统综述。
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