Laurindo Lucas Fornari, de Carvalho Gabriel Magno, de Oliveira Zanuso Bárbara, Figueira Maria Eduardo, Direito Rosa, de Alvares Goulart Ricardo, Buglio Daiene Santos, Barbalho Sandra Maria
Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Avenida Hygino Muzzy Filho, 1001, Marília, São Paulo 17525-902, Brazil.
Laboratory of Systems Integration Pharmacology, Clinical & Regulatory Science, Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.
Pharmaceutics. 2023 Jan 10;15(1):229. doi: 10.3390/pharmaceutics15010229.
Curcumin (CUR) is a polyphenol extracted from the rhizome of that possesses potent anti-inflammatory and antioxidant potential. Despite CUR's numerous beneficial effects on human health, it has limitations, such as poor absorption. Nano-based drug delivery systems have recently been applied to improve CUR's solubility and bioavailability and potentialize its health effects. This review investigated the effects of different CUR-based nanomedicines on inflammatory and immunomodulated diseases. PUBMED, EMBASE, COCHRANE, and GOOGLE SCHOLAR databases were searched, and the Scale for Assessment of Narrative Review Articles (SANRA) was used for quality assessment and PRISMA guidelines. Overall, 66 studies were included comprising atherosclerosis, rheumatoid arthritis (RA), Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), Huntington's disease (HD), inflammatory bowel diseases (IBD), psoriasis, liver fibrosis, epilepsy, and COVID-19. The available scientific studies show that there are many known nanoformulations with curcumin. They can be found in nanosuspensions, nanoparticles, nanoemulsions, solid lipid particles, nanocapsules, nanospheres, and liposomes. These formulations can improve CUR bioavailability and can effectively be used as adjuvants in several inflammatory and immune-mediated diseases such as atheroma plaque formation, RA, dementia, AD, PD, MS, IBD, psoriasis, epilepsy, COVID-19, and can be used as potent anti-fibrotic adjuvants in fibrotic liver disease.
姜黄素（CUR）是从姜黄根茎中提取的一种多酚，具有强大的抗炎和抗氧化潜力。尽管CUR对人类健康有诸多益处，但它也有局限性，比如吸收性差。基于纳米的药物递送系统最近已被应用于提高CUR的溶解度和生物利用度，并增强其对健康的影响。本综述研究了不同的基于CUR的纳米药物对炎症和免疫调节疾病的影响。检索了PUBMED、EMBASE、COCHRANE和谷歌学术数据库，并使用叙述性综述文章评估量表（SANRA）进行质量评估以及遵循PRISMA指南。总体而言，纳入了66项研究，涉及动脉粥样硬化、类风湿性关节炎（RA）、阿尔茨海默病（AD）、帕金森病（PD）、多发性硬化症（MS）、亨廷顿舞蹈病（HD）、炎症性肠病（IBD）、银屑病、肝纤维化、癫痫和新冠肺炎。现有的科学研究表明，有许多已知的含姜黄素的纳米制剂。它们存在于纳米混悬液、纳米颗粒、纳米乳剂、固体脂质颗粒、纳米胶囊、纳米球和脂质体中。这些制剂可以提高CUR的生物利用度，并能有效地用作几种炎症和免疫介导疾病的佐剂，如动脉粥样斑块形成、RA、痴呆、AD、PD、MS、IBD、银屑病、癫痫、新冠肺炎，还可以用作肝纤维化疾病中强大的抗纤维化佐剂。
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