通过亚硫酸钠实现的吲哚与碘氟乙烷的直接氟烷基硫醇化反应
Direct fluoroalkylthiolation of indoles with iodofluoroethane enabled by NaSO.
作者信息
Yu Nianhua, Huang Jianjian, Leng Faqiang
机构信息
School of Pharmaceutical Sciences, Capital Medical University Beijing 100069 P. R. China
出版信息
RSC Adv. 2023 Jan 3;13(1):730-733. doi: 10.1039/d2ra07430c. eCollection 2022 Dec 19.
In this paper, we report an efficient approach for the direct fluoroalkylthiolation of indoles with iodofluoroethane in the presence of NaSO. In this work, we employed readily available iodofluoroethane and NaSO as fluoroalkylthiolation reagents, featuring mild conditions and a wide range of indole substrates. In addition, fluoroalkylthiolated 2,3'-biindole derivatives can also be prepared by this method.
在本文中，我们报道了一种在NaSO存在下用碘氟乙烷对吲哚进行直接氟烷基硫醇化的有效方法。在这项工作中，我们使用了易于获得的碘氟乙烷和NaSO作为氟烷基硫醇化试剂，该方法条件温和，吲哚底物范围广泛。此外，氟烷基硫醇化的2,3'-联吲哚衍生物也可以通过该方法制备。
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