Nojima Hiroyuki, Shimizu Hiroaki, Murakami Takashi, Yamazaki Masato, Yamazaki Kazuto, Suzuki Seiya, Shuto Kiyohiko, Kosugi Chihiro, Usui Akihiro, Koda Keiji
Department of Surgery, Teikyo University Chiba Medical Center, Ichihara, Japan.
Department of Pathology, Teikyo University Chiba Medical Center, Ichihara, Japan.
Front Med (Lausanne). 2023 Jan 6;9:1092879. doi: 10.3389/fmed.2022.1092879. eCollection 2022.
Invasive -associated liver abscesses can progress rapidly and cause severe metastatic infections such as meningitis and hydrocephalus, which are associated with high morbidity and mortality. In patients with large multiloculated liver abscesses after failure of percutaneous drainage, rapid diagnosis of the abscess followed by hepatic resection is necessary for early recovery and to prevent severe secondary metastatic complications.
An 84-year-old woman with a large liver abscess and in septic shock was transferred to our hospital. Abdominal CT showed multiloculated liver abscesses 15 cm in diameter in the right lobe of the liver. We first performed percutaneous liver abscess drainage. The patient was managed in the intensive care unit, as well as treated with intravenous administration of meropenem followed by cefozopran according to the antibiogram. with invasive infection was confirmed by a string test in an isolated colony of ; the K1 serotype with the and genes was determined by polymerase chain reaction and Sanger sequencing. Additional percutaneous liver abscess drainage was performed due to initial inadequate drainage. Although the abscess had shrunk to a diameter of 8 cm after drainage in 4 weeks, the patient recovered from sepsis, but still had low-grade fever (occasionally 38°C) and continued to have symptoms of chronic inflammation with persistent hyper mucus discharge from the liver abscess. Surgical resection was chosen to prevent prolonged hospitalization and ensure early recovery. A right posterior sectionectomy of the liver, including liver abscess, was performed. The post-operative course was uneventful, with no complications, and she was discharged after 18 days. There were no signs of abscess recurrence 1 year after surgery.
We present a case of successful hepatic resection after percutaneous drainage failure in a patient with invasive multiloculated liver abscess.
侵袭性相关肝脓肿可迅速进展并引起严重的转移性感染,如脑膜炎和脑积水,这些感染与高发病率和死亡率相关。对于经皮引流失败后出现巨大多房性肝脓肿的患者,快速诊断脓肿并进行肝切除对于早期康复和预防严重的继发性转移性并发症是必要的。
一名84岁患有巨大肝脓肿并处于感染性休克的女性被转至我院。腹部CT显示肝脏右叶有直径15厘米的多房性肝脓肿。我们首先进行了经皮肝脓肿引流。患者在重症监护病房接受治疗,并根据抗菌谱先静脉注射美罗培南,随后注射头孢唑肟。通过对分离菌落进行串珠试验确认存在侵袭性感染;通过聚合酶链反应和桑格测序确定了具有 和 基因的K1血清型。由于初始引流不充分,进行了额外的经皮肝脓肿引流。尽管4周引流后脓肿直径缩小至8厘米,但患者从败血症中康复,但仍有低热(偶尔38°C),并且持续存在慢性炎症症状,肝脓肿持续有大量黏液排出。为防止长期住院并确保早期康复,选择了手术切除。进行了包括肝脓肿在内的肝脏右后叶切除术。术后过程顺利,无并发症,18天后出院。术后1年无脓肿复发迹象。
我们报告了一例侵袭性多房性肝脓肿患者经皮引流失败后成功进行肝切除的病例。