心磷脂在后生动物分化、发育和成熟中的关键作用。
The critical role of cardiolipin in metazoan differentiation, development, and maturation.
机构信息
Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, USA.
Department of Anesthesiology, New York University Grossman School of Medicine, New York, New York, USA.
出版信息
Dev Dyn. 2023 Jun;252(6):691-712. doi: 10.1002/dvdy.567. Epub 2023 Feb 9.
Cardiolipins are phospholipids that are central to proper mitochondrial functioning. Because mitochondria play crucial roles in differentiation, development, and maturation, we would also expect cardiolipin to play major roles in these processes. Indeed, cardiolipin has been implicated in the mechanism of three human diseases that affect young infants, implying developmental abnormalities. In this review, we will: (1) Review the biology of cardiolipin; (2) Outline the evidence for essential roles of cardiolipin during organismal development, including embryogenesis and cell maturation in vertebrate organisms; (3) Place the role(s) of cardiolipin during embryogenesis within the larger context of the roles of mitochondria in development; and (4) Suggest avenues for future research.
心磷脂是一种磷脂，对于线粒体的正常功能至关重要。由于线粒体在分化、发育和成熟过程中起着关键作用，我们也期望心磷脂在这些过程中发挥重要作用。事实上，心磷脂与三种影响婴幼儿的人类疾病的发病机制有关，这意味着发育异常。在这篇综述中，我们将：（1） 综述心磷脂的生物学特性；（2） 概述心磷脂在机体发育过程中的重要作用，包括脊椎动物的胚胎发生和细胞成熟；（3） 将心磷脂在胚胎发生中的作用置于线粒体在发育中的作用的更大背景下；（4） 提出未来研究的途径。
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