连续性肾脏替代疗法对急性肾损伤患者急性生理与慢性健康状况评分系统-II、肌酐及尿素氮水平的影响

Effects of continuous renal replacement therapy on Apache-II score, creatinine, and urea nitrogen Levels in patients with acute kidney injury.

作者信息

Hou Huihui, Li Lingzhi

机构信息

Huihui Hou, Department of Intensive Care Unit, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University No.11, Wuyingshan Middle Road, Jinan 250031, Shandong Province, P.R. China.

Lingzhi Li, Department of Intensive Care Unit, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University No.11, Wuyingshan Middle Road, Jinan 250031, Shandong Province, P.R. China.

出版信息

Pak J Med Sci. 2023 Jan-Feb;39(1):50-54. doi: 10.12669/pjms.39.1.6591.

DOI:10.12669/pjms.39.1.6591

PMID:36694734

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9843020/

Abstract

OBJECTIVE

To analyze the effects of continuous renal replacement therapy (CRRT) on acute physiology and chronic health scoring system II (APACHE-II) score, creatinine, and urea nitrogen levels in patients with acute kidney injury (AKI).

METHODS

Medical records of 79 patients with AKI treated in Shandong Provincial Third Hospital from January 2019 to January 2021 were retrospectively divided into two groups based on the received treatment. Of them 37 patients received intermittent hemodialysis (IHD) treatment (control group) and 42 patients received CRRT (observation group). Clinical efficacy, survival rate, severity of disease, renal function and serum electrolytels and fluid balance were analyzed.

RESULTS

After the treatment, the total efficacy of the observation group was 95.24%, and the 6-month survival rate was 97.62%, which was higher than 81.08% and 83.78% in the control group, respectively (<0.05). The Apache-II score of the observation group was (15.76±4.29), which was lower than that of the control group (23.62±5.37). Levels of creatinine, urea nitrogen, and serum levels of potassium (K), chlorine (Cl-) and sodium (Na) in the observation group were lower than those in the control group (<0.05).

CONCLUSION

CRRT can achieve significant results in the treatment of patients with AKI, help to improve the curative effect, survival rate, alleviate the severity of the disease, recovery of renal functions, the recovery of serum electrolytels and fluid balance.

摘要

目的

分析连续性肾脏替代治疗（CRRT）对急性肾损伤（AKI）患者急性生理与慢性健康评分系统II（APACHE-II）评分、肌酐及尿素氮水平的影响。

方法

回顾性分析2019年1月至2021年1月在山东省立第三医院接受治疗的79例AKI患者的病历资料，根据所接受的治疗方法将其分为两组。其中37例患者接受间歇性血液透析（IHD）治疗（对照组），42例患者接受CRRT治疗（观察组）。分析临床疗效、生存率、疾病严重程度、肾功能、血清电解质及液体平衡情况。

结果

治疗后，观察组总有效率为95.24%，6个月生存率为97.62%，分别高于对照组的81.08%和83.78%（P<0.05）。观察组的Apache-II评分为（15.76±4.29），低于对照组（23.62±5.37）。观察组的肌酐、尿素氮水平以及血清钾（K）、氯（Cl-）和钠（Na）水平均低于对照组（P<0.05）。