儿科内镜检查时，从十二指肠获取额外的肠道黏膜研究活检并不会增加风险。
No Increased Risk of Taking Additional Intestinal Mucosal Research Biopsies From the Duodenum During Pediatric Endoscopy.
机构信息
From the Division of Pediatric Gastroenterology, Department of Pediatrics, MassGeneral Hospital for Children, Harvard Medical School, Boston, MA.
the Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA.
出版信息
J Pediatr Gastroenterol Nutr. 2023 Apr 1;76(4):480-482. doi: 10.1097/MPG.0000000000003723. Epub 2023 Jan 25.
Studies involving human intestinal tissue are essential for advancing the field of celiac disease (CeD), as diagnosis requires duodenal biopsies. Performing studies in children helps to better understand CeD in this important subpopulation. This study aims to determine the risk in obtaining duodenal research biopsies during pediatric endoscopy. In this retrospective chart review from 2016 to 2022 of 1180 research subjects and controls, there were 18 procedure-related adverse events within 48 hours. Most adverse events were for symptoms of pain and fever. There was no increased risk of adverse events if additional duodenal research biopsies were taken during pediatric endoscopy.
涉及人类肠道组织的研究对于推动乳糜泻（CeD）领域的发展至关重要，因为诊断需要十二指肠活检。在儿童中进行研究有助于更好地了解这一重要亚群中的 CeD。本研究旨在确定在儿科内镜检查期间获取十二指肠研究活检的风险。在这项 2016 年至 2022 年期间对 1180 名研究对象和对照者进行的回顾性图表审查中，有 18 例与操作相关的不良事件在 48 小时内发生。大多数不良事件表现为疼痛和发热症状。如果在儿科内镜检查期间进行额外的十二指肠研究活检，不良事件的风险没有增加。
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