Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Cell Commun Signal. 2023 Jan 31;21(1):28. doi: 10.1186/s12964-023-01043-1.
The MYC oncogenic family is dysregulated in diverse tumors which is generally linked to the poor prognosis of tumors. The members in MYC family are transcription factors which are responsible for the regulation of various genes expression. Among them, c-MYC is closely related to the progression of tumors. Furthermore, c-MYC aberrations is tightly associated with the prevalence of breast cancer. Tumor microenvironment (TME) is composed of many different types of cellular and non-cellular factors, mainly including cancer-associated fibroblasts, tumor-associated macrophages, vascular endothelial cells, myeloid-derived suppressor cells and immune cells, all of which can affect the diagnosis, prognosis, and therapeutic efficacy of breast cancer. Importantly, the biological processes occurred in TME, such as angiogenesis, immune evasion, invasion, migration, and the recruition of stromal and tumor-infiltrating cells are under the modulation of c-MYC. These findings indicated that c-MYC serves as a critical regulator of TME. Here, we aimed to summarize and review the relevant research, thus to clarify c-MYC is a key mediator between breast cancer cells and TME. Video Abstract.
MYC 癌基因家族在多种肿瘤中失调，通常与肿瘤的预后不良有关。MYC 家族的成员是转录因子，负责调节各种基因的表达。其中，c-MYC 与肿瘤的进展密切相关。此外，c-MYC 异常与乳腺癌的高发密切相关。肿瘤微环境（TME）由许多不同类型的细胞和非细胞因素组成，主要包括癌相关成纤维细胞、肿瘤相关巨噬细胞、血管内皮细胞、髓源性抑制细胞和免疫细胞，它们都可以影响乳腺癌的诊断、预后和治疗效果。重要的是，TME 中发生的生物学过程，如血管生成、免疫逃逸、侵袭、迁移以及基质和肿瘤浸润细胞的募集，都受到 c-MYC 的调节。这些发现表明 c-MYC 是 TME 的关键调节因子。在这里，我们旨在总结和回顾相关研究，从而阐明 c-MYC 是乳腺癌细胞与 TME 之间的关键介质。视频摘要。
