From the School of Population and Public Health, The University of British Columbia, Vancouver, BC, Canada.
Department of Obstetrics & Gynaecology, The University of British Columbia, Vancouver, BC, Canada.
Epidemiology. 2023 Mar 1;34(2):265-270. doi: 10.1097/EDE.0000000000001569. Epub 2022 Nov 29.
Prevalence statistics for pregnancy complications identified through screening such as gestational diabetes usually assume universal screening. However, rates of screening completion in pregnancy are not available in many birth registries or hospital databases. We validated screening-test completion by comparing public insurance laboratory and radiology billing records with medical records at three hospitals in British Columbia, Canada.
We abstracted a random sample of 140 delivery medical records (2014-2019), and successfully linked 127 to valid provincial insurance billings and maternal-newborn registry data. We compared billing records for gestational diabetes screening, any ultrasound before 14 weeks gestational age, and Group B streptococcus screening during each pregnancy to the gold standard of medical records by calculating sensitivity and specificity, positive predictive value, negative predictive value, and prevalence with 95% confidence intervals (CIs).
Gestational diabetes screening (screened vs. unscreened) in billing records had a high sensitivity (98% [95% CI = 93, 100]) and specificity (>99% [95% CI = 86, 100]). The use of specific glucose screening approaches (two-step vs. one-step) were also well characterized by billing data. Other tests showed high sensitivity (ultrasound 97% [95% CI = 92, 99]; Group B streptococcus 96% [95% CI = 89, 99]) but lower negative predictive values (ultrasound 64% [95% CI = 33, 99]; Group B streptococcus 70% [95% CI = 40, 89]). Lower negative predictive values were due to the high prevalence of these screening tests in our sample.
Laboratory and radiology insurance billing codes accurately identified those who completed routine antenatal screening tests with relatively low false-positive rates.
通过筛查(如妊娠期糖尿病)识别出的妊娠并发症的流行统计数据通常假定进行了普遍筛查。然而,在许多出生登记处或医院数据库中,并没有筛查完成率的相关数据。我们通过比较不列颠哥伦比亚省的三家医院的公共保险实验室和放射科计费记录与医疗记录,验证了筛查测试的完成情况。
我们从 2014 年至 2019 年的分娩医疗记录中随机抽取了 140 份记录,并成功将其中的 127 份与有效的省级保险计费和母婴登记数据相关联。我们比较了妊娠糖尿病筛查、任何在妊娠 14 周前进行的超声检查以及每次妊娠的 B 组链球菌筛查的计费记录与医疗记录的金标准,通过计算灵敏度和特异性、阳性预测值、阴性预测值和流行率(95%置信区间)来比较。
计费记录中妊娠糖尿病筛查(筛查与未筛查)的灵敏度很高(98%[95%置信区间=93,100]),特异性也很高(>99%[95%置信区间=86,100])。计费数据还很好地描述了特定的葡萄糖筛查方法(两步法与一步法)。其他测试的灵敏度也很高(超声 97%[95%置信区间=92,99];B 组链球菌 96%[95%置信区间=89,99]),但阴性预测值较低(超声 64%[95%置信区间=33,99];B 组链球菌 70%[95%置信区间=40,89])。较低的阴性预测值是由于我们的样本中这些筛查测试的高患病率所致。
实验室和放射科保险计费代码准确地识别出了完成常规产前筛查测试的人群,其假阳性率相对较低。