State Disease Diagnostic Centre, Department of Animal Husbandry, 302001, Jaipur, Rajasthan, India.
CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, 110025, Delhi, India.
Arch Virol. 2023 Feb 5;168(3):81. doi: 10.1007/s00705-023-05705-w.
Although previously confined to regions within Africa, lumpy skin disease virus (LSDV) infections have caused significantly large outbreaks in several regions of the world in recent years. In 2019, an outbreak of the disease was reported in India with low rates of morbidity and no reported mortality. However, in 2022, an ongoing outbreak of LSDV spanning over seven states in India resulted in the loss of over 80,000 cattle over a period of three months. Here, we report complete genome sequences of six isolates of LSDV collected from affected cattle during an ongoing outbreak of the disease in Rajasthan, India. Analysis of these sequences showed that the genome isolates from the 2022 outbreak have a large number of genetic variations compared to the reference strain and that they form a distinct genetic lineage. This report thus highlights the importance of genome sequencing and surveillance of transboundary infectious agents to track the prevalence and emergence of variants.
虽然以前局限于非洲的一些地区，但近年来，块状皮肤病病毒（LSDV）感染已在世界上几个地区引起了严重的大爆发。2019 年，印度报告了该病的爆发，发病率低，没有报告死亡。然而，2022 年，印度七个邦持续爆发 LSDV，三个月内导致超过 8 万头牛死亡。在这里，我们报告了从印度拉贾斯坦邦正在爆发的疾病中受感染的牛身上采集的六个 LSDV 分离株的完整基因组序列。这些序列的分析表明，与参考株相比，2022 年爆发的基因组分离株有大量的遗传变异，并且它们形成了一个独特的遗传谱系。因此，本报告强调了对跨境传染病原体进行基因组测序和监测以跟踪变体的流行和出现的重要性。
