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中风后影响神经发生的因素及针灸的作用。

The factors affecting neurogenesis after stroke and the role of acupuncture.

作者信息

Mu Jie-Dan, Ma Liang-Xiao, Zhang Zhou, Qian Xu, Zhang Qin-Yong, Ma Ling-Hui, Sun Tian-Yi

机构信息

School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.

The Key Unit of State Administration of Traditional Chines Medicine, Evaluation of Characteristic Acupuncture Therapy, Beijing, China.

出版信息

Front Neurol. 2023 Jan 20;14:1082625. doi: 10.3389/fneur.2023.1082625. eCollection 2023.

Abstract

Stroke induces a state of neuroplasticity in the central nervous system, which can lead to neurogenesis phenomena such as axonal growth and synapse formation, thus affecting stroke outcomes. The brain has a limited ability to repair ischemic damage and requires a favorable microenvironment. Acupuncture is considered a feasible and effective neural regulation strategy to improve functional recovery following stroke the benign modulation of neuroplasticity. Therefore, we summarized the current research progress on the key factors and signaling pathways affecting neurogenesis, and we also briefly reviewed the research progress of acupuncture to improve functional recovery after stroke by promoting neurogenesis. This study aims to provide new therapeutic perspectives and strategies for the recovery of motor function after stroke based on neurogenesis.

摘要

中风会在中枢神经系统中诱导一种神经可塑性状态,这可能导致轴突生长和突触形成等神经发生现象,从而影响中风的预后。大脑修复缺血性损伤的能力有限,需要一个有利的微环境。针灸被认为是一种可行且有效的神经调节策略,可通过对神经可塑性的良性调节来改善中风后的功能恢复。因此,我们总结了目前关于影响神经发生的关键因素和信号通路的研究进展,还简要回顾了针灸通过促进神经发生来改善中风后功能恢复的研究进展。本研究旨在基于神经发生为中风后运动功能恢复提供新的治疗观点和策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa14/9895425/709005e750cc/fneur-14-1082625-g0001.jpg

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