Francisco Elaine Cristina, Hagen Ferry
Division of Infectious Diseases, Escola Paulista de Medicina-Universidade Federal de São Paulo, São Paulo 04039-032, Brazil.
Westerdijk Fungal Biodiversity Institute, Uppsalalaan 8, 3584 CT, Utrecht, Netherlands.
J Med Microbiol. 2022 Dec;71(12). doi: 10.1099/jmm.0.001621.
yeasts are classical agents of superficial mycoses, and they are ranked as the first to second predominant basidiomycetous yeast able to cause invasive infections. The clinical presentation of infections varies with the affected anatomical site, with fungaemia present in the majority of invasive trichosporonosis cases. Only a limited number of antifungal compounds can be used to treat infections. Azoles are the first choice due to their intrinsic resistance to echinocandins. Better laboratory methods and up-to-date databases of commercial platforms are required to improve identification, susceptibility testing and surveillance of this potentially threating infection.
酵母是浅表真菌病的典型病原体,它们被列为能够引起侵袭性感染的第一至第二主要担子菌酵母。感染的临床表现因受影响的解剖部位而异,大多数侵袭性毛孢子菌病病例中存在真菌血症。只有有限数量的抗真菌化合物可用于治疗感染。由于唑类对棘白菌素具有内在抗性,因此是首选药物。需要更好的实验室方法和商业平台的最新数据库来改善对这种潜在威胁性感染的鉴定、药敏试验和监测。