基于异质结构 AgPO/Ag/TiO 纳米棒阵列的双功能光电化学适体传感器用于两种肿瘤标志物的测定。
Bifunctional photoelectrochemical aptasensor based on heterostructured AgPO/Ag/TiO nanorod array for determination of two tumor markers.
机构信息
Central Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, China.
College of Geography and Environmental Sciences, College of Chemistry and Life Sciences, Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Zhejiang Normal University, Jinhua, 321004, China.
出版信息
Mikrochim Acta. 2023 Feb 7;190(3):85. doi: 10.1007/s00604-023-05654-w.
Constructing of heterostructures can significantly improve the photoelectrical (PEC) response signal by promoting the migration and suppressing the recombination of photogenerated carries. A bifunctional PEC sensing platform was designed for simultaneous high-performance detection of mucin-1 (MUC1) and carcinoembryonic antigen (CEA), which was based on generated Z-scheme heterostructured AgPO/Ag/TiO nanorod arrays (NAs) and enzyme-mediated catalytic precipitation by alkaline phosphatase (ALP) and Au/hollow CoO polyhedron. The proposed aptasensor displayed linear ranges of 1.0-100 ng mL and 0.1-50 ng mL for MUC1 and CEA with limit of detections of 0.430 and 0.058 ng mL, respectively. This strategy offers potential applications for early diagnosis, monitoring progression, and even evaluating the prognosis of breast cancer in practice.
构建异质结构可以通过促进光生载流子的迁移和抑制复合来显著提高光电（PEC）响应信号。基于碱性磷酸酶（ALP）和 Au/空心 CoO 多面体的酶介导的催化沉淀，设计了一种用于同时高灵敏度检测黏蛋白-1（MUC1）和癌胚抗原（CEA）的双功能 PEC 传感平台，该平台基于生成的 Z 型异质结构 AgPO/Ag/TiO 纳米棒阵列（NAs）。所提出的适体传感器对 MUC1 和 CEA 的线性范围分别为 1.0-100ng mL 和 0.1-50ng mL，检测限分别为 0.430ng mL 和 0.058ng mL。该策略为乳腺癌的早期诊断、监测进展甚至评估预后提供了实际应用潜力。
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