术后恶心在全身麻醉后次日给予昂丹司琼后出现嗜睡：一例儿科病例报告。
Drowsiness following ondansetron given the day after general anesthesia for postoperative nausea: a pediatric case report.
作者信息
Furuta Machiko, Miyasaka Kiyoyuki, Suzuki Yasuyuki
机构信息
Department of Critical Care and Anesthesia, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.
出版信息
JA Clin Rep. 2023 Feb 9;9(1):8. doi: 10.1186/s40981-023-00599-8.
BACKGROUND
Ondansetron is an antiemetic drug that is useful not only for prevention but also for the treatment of postoperative nausea and vomiting (PONV). We report a rare case of drowsiness in a child after using ondansetron for nausea on the day after general anesthesia.
CASE PRESENTATION
A 5-year-old boy underwent circumcision under general anesthesia and suffered from postoperative nausea and vomiting. He was administered 0.1mg/kg of ondansetron in the PACU and 23 h later on the day after surgery. After the second dose, he acutely exhibited drowsiness which resolved in 3 h. He was discharged to home later on the same day. He was not given any other drugs at the time, and the drowsiness was thought to be directly attributable to ondansetron, though the exact mechanism was unknown.
CONCLUSIONS
When drowsiness or other cognitive symptoms are observed after administration of ondansetron, it must be considered and managed as a possible side effect.
背景
昂丹司琼是一种止吐药物，不仅可用于预防，还可用于治疗术后恶心和呕吐（PONV）。我们报告了一例罕见病例，一名儿童在全身麻醉后第二天使用昂丹司琼治疗恶心后出现嗜睡。
病例介绍
一名5岁男孩在全身麻醉下行包皮环切术，术后出现恶心和呕吐。他在麻醉后护理单元（PACU）以及术后第二天23小时时分别接受了0.1mg/kg的昂丹司琼治疗。第二次用药后，他突然出现嗜睡，并在3小时内缓解。他于同一天晚些时候出院。当时他未服用任何其他药物，虽然确切机制尚不清楚，但嗜睡被认为直接归因于昂丹司琼。
结论
当在使用昂丹司琼后观察到嗜睡或其他认知症状时，必须将其作为一种可能的副作用加以考虑和处理。
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