Maier H, Sziegoleit A, Merck S
Hals-Nasen-Ohrenklinik, Justus-Liebig-Universität, Giessen, Fed. Rep. of Germany.
Arzneimittelforschung. 1987 Jul;37(7):797-8.
The penetration of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid (ciprofloxacin, Bay o 9867, Ciprobay) into parotid gland tissue and parotid saliva of the rat after intravenous administration (6 mg/kg body weight) was studied. 2 h after bolus injection ciprofloxacin mean levels in parotid gland tissue (0.60 mg/l) nearly reached 2-fold mean blood levels (0.36 mg/l). In parotid saliva the mean concentration of the gyrase inhibitor (0.20 mg/l) was lower than in blood, however, still high enough to be effective against the pathogens which most often cause inflammation of the parotid gland.
研究了静脉注射（6毫克/千克体重）1-环丙基-6-氟-1,4-二氢-4-氧代-7-(1-哌嗪基)-3-喹啉羧酸（环丙沙星，拜耳o 9867，拜复乐）后，其在大鼠腮腺组织和腮腺唾液中的渗透情况。推注注射后2小时，环丙沙星在腮腺组织中的平均水平（0.60毫克/升）几乎达到平均血药浓度（0.36毫克/升）的2倍。在腮腺唾液中，该喹诺酮类抑制剂的平均浓度（0.20毫克/升）低于血液中的浓度，然而，仍足以有效对抗最常引起腮腺炎症的病原体。
