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提高 2021 年在埃塞俄比亚新生儿重症监护病房住院的早产儿低血糖症的检出率。

Maximizing the detection rate of hypoglycemia among preterm neonates admitted in Neonatal intensive care unit in Ethiopia, 2021.

机构信息

Debre Tabor University, Debre Tabor, Ethiopia.

Debre Tabor Health Science College, Debre Tabor, Ethiopia.

出版信息

Sci Rep. 2023 Feb 9;13(1):2283. doi: 10.1038/s41598-023-29112-y.

Abstract

The burden of hypoglycemia is high in resource limited countries, such as Ethiopia. However, there are no sufficient studies conducted in Ethiopia in general and in the study setting in particular in the previous era. Hence, this study aims to assess the proportion of hypoglycemia and associated factors among preterm neonates admitted to the neonatal intensive care unit at Debre Tabor Comprehensive Specialized Hospital, Ethiopia, in 2021. A hospital-based cross-sectional study was conducted from October 1 to December 30, 2021, at Debre Tabor Comprehensive Specialized Hospital in the neonatal intensive care unit ward. The data was entered in Epi-info 7 and exported to STATA version 14. A binary and multivariable logistic regression was computed at 95% confidence interval (CI). During bivariable analysis, variables having a p-value of less than 0.25 were chosen for multivariable logistic regression analysis, and variables having a p-value of less than 0.05 in multivariable analysis, were significant associations with the dependent variable. The study included 267 preterm neonates, and 23.59% (95% CI 18.9-29.1) were develop hypoglycemia. Moreover, 49 (18.35%) preterm neonates died during the study period. In this study, preterm neonates with hypothermia [Adjusted Odds Ratio (AOR = 4.5; 95 CI 3.4, 7.2)], birth asphyxia (AOR = 5.1; 95 CI 3.9, 27.1), seizure (AOR = 4.7; 95 CI 2.8, 17.8), and also preterm neonates born from diabetic mothers (AOR = 6.7; 95 CI 3.3, 27.2) were significantly associated with the occurrence of hypoglycemia in the neonatal intensive care. The proportion of hypoglycemia and associated factors among preterm neonates admitted to the neonatal intensive care unit at Debre Tabor Comprehensive Specialized Hospital was found to be high. The associated factors for the occurrence of hypoglycemia were discovered to be neonates with hypothermia, birth asphyxia, seizure, and neonates born with a diabetes mother. Thus, recognizing and treating the above associated factors is essential to preventing, and controlling hypoglycemia.

摘要

在资源有限的国家,如埃塞俄比亚,低血糖的负担很高。然而,在以往的时代,埃塞俄比亚一般没有足够的研究,特别是在研究环境中。因此,本研究旨在评估 2021 年在埃塞俄比亚德布雷塔博尔综合专科医院新生儿重症监护病房住院的早产儿低血糖的比例及其相关因素。2021 年 10 月 1 日至 12 月 30 日,在德布雷塔博尔综合专科医院新生儿重症监护病房进行了一项基于医院的横断面研究。数据输入 Epi-info 7 并导出到 STATA 版本 14。在 95%置信区间(CI)下计算了二项式和多变量逻辑回归。在双变量分析中,选择 p 值小于 0.25 的变量进行多变量逻辑回归分析,在多变量分析中 p 值小于 0.05 的变量与因变量有显著关联。该研究包括 267 名早产儿,23.59%(95%CI 18.9-29.1)发生低血糖。此外,在研究期间,有 49 名(18.35%)早产儿死亡。在这项研究中,患有低体温的早产儿[调整后的优势比(AOR=4.5;95%CI 3.4,7.2)]、出生窒息(AOR=5.1;95%CI 3.9,27.1)、癫痫发作(AOR=4.7;95%CI 2.8,17.8)以及患有糖尿病母亲的早产儿(AOR=6.7;95%CI 3.3,27.2)与新生儿重症监护中低血糖的发生显著相关。在德布雷塔博尔综合专科医院新生儿重症监护病房住院的早产儿中,低血糖的比例和相关因素都很高。发现低血糖发生的相关因素是低体温、出生窒息、癫痫发作和糖尿病母亲所生的早产儿。因此,识别和治疗上述相关因素对于预防和控制低血糖至关重要。

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