Department of Evidence-Based Medicine, Southwest Medical University, Luzhou, Sichuan, China.
Department of Laboratory Medicine, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Front Immunol. 2023 Jan 25;13:1073971. doi: 10.3389/fimmu.2022.1073971. eCollection 2022.
Hypoxia-inducible factor-1α (HIF-1α) is a primary metabolic sensor, and is expressed in different immune cells, such as macrophage, dendritic cell, neutrophil, T cell, and non-immune cells, for instance, synovial fibroblast, and islet β cell. HIF-1α signaling regulates cellular metabolism, triggering the release of inflammatory cytokines and inflammatory cells proliferation. It is known that microenvironment hypoxia, vascular proliferation, and impaired immunological balance are present in autoimmune diseases. To date, HIF-1α is recognized to be overexpressed in several inflammatory autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis, and function of HIF-1α is dysregulated in these diseases. In this review, we narrate the signaling pathway of HIF-1α and the possible immunopathological roles of HIF-1α in autoimmune diseases. The collected information will provide a theoretical basis for the familiarization and development of new clinical trials and treatment based on HIF-1α and inflammatory autoimmune disorders in the future.
缺氧诱导因子-1α（HIF-1α）是一种主要的代谢传感器，在不同的免疫细胞中表达，如巨噬细胞、树突状细胞、中性粒细胞、T 细胞和非免疫细胞，如滑膜成纤维细胞和胰岛β细胞。HIF-1α信号调节细胞代谢，触发炎症细胞因子的释放和炎症细胞的增殖。已知在自身免疫性疾病中存在微环境缺氧、血管增殖和免疫平衡受损。迄今为止，HIF-1α被认为在几种炎症性自身免疫性疾病中过度表达，如系统性红斑狼疮（SLE）、类风湿关节炎，并且 HIF-1α的功能在这些疾病中失调。在这篇综述中，我们描述了 HIF-1α的信号通路以及 HIF-1α在自身免疫性疾病中的可能免疫病理作用。收集的信息将为未来基于 HIF-1α和炎症性自身免疫疾病的新临床试验和治疗的熟悉和发展提供理论基础。
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