Department of Nephrology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Department of Neurology, Yantai Yuhuangding Hospital, Shandong University, Yantai, China.
Front Immunol. 2023 Jan 26;14:1084448. doi: 10.3389/fimmu.2023.1084448. eCollection 2023.
Diabetic kidney disease (DKD) is the most common cause of end-stage renal disease and has gradually become a public health problem worldwide. DKD is increasingly recognized as a comprehensive inflammatory disease that is largely regulated by T cells. Given the pivotal role of T cells and T cells-producing cytokines in DKD, we summarized recent advances concerning T cells in the progression of type 2 diabetic nephropathy and provided a novel perspective of immune-related factors in diabetes. Specific emphasis is placed on the classification of T cells, process of T cell recruitment, function of T cells in the development of diabetic kidney damage, and potential treatments and therapeutic strategies involving T cells.
糖尿病肾病（DKD）是终末期肾病的最常见原因，已逐渐成为全球范围内的公共卫生问题。DKD 被广泛认为是一种全身性炎症性疾病，主要受 T 细胞调控。鉴于 T 细胞及其产生的细胞因子在 DKD 中的关键作用，我们总结了 T 细胞在 2 型糖尿病肾病进展中的最新研究进展，并为糖尿病中与免疫相关的因素提供了新的视角。重点介绍了 T 细胞的分类、T 细胞募集的过程、T 细胞在糖尿病肾损伤发展中的作用，以及涉及 T 细胞的潜在治疗方法和治疗策略。
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