Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Division of Nephrology, Department of Medicine, School of Medicine, University of Connecticut Health Center, Farmington, CT, United States.
Front Immunol. 2023 Jan 26;14:1125246. doi: 10.3389/fimmu.2023.1125246. eCollection 2023.
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a pandemic named coronavirus disease 2019 (COVID-19) that has become the greatest worldwide public health threat of this century. Recent studies have unraveled numerous mysteries of SARS-CoV-2 pathogenesis and thus largely improved the studies of COVID-19 vaccines and therapeutic strategies. However, important questions remain regarding its therapy. In this review, the recent research advances on COVID-19 mechanism are quickly summarized. We mainly discuss current therapy strategies for COVID-19, with an emphasis on antiviral agents, neutralizing antibody therapies, Janus kinase inhibitors, and steroids. When necessary, specific mechanisms and the history of therapy are present, and representative strategies are described in detail. Finally, we discuss key outstanding questions regarding future directions of the development of COVID-19 treatment.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的出现引发了一场大流行，被命名为 2019 年冠状病毒病（COVID-19），这是本世纪全球面临的最大公共卫生威胁。最近的研究揭示了 SARS-CoV-2 发病机制的许多奥秘，从而大大改进了 COVID-19 疫苗和治疗策略的研究。然而，其治疗仍存在一些重要问题。在这篇综述中，我们快速总结了 COVID-19 发病机制的最新研究进展。我们主要讨论了 COVID-19 的当前治疗策略，重点是抗病毒药物、中和抗体疗法、Janus 激酶抑制剂和类固醇。在必要时，我们介绍了特定的机制和治疗历史，并详细描述了有代表性的策略。最后，我们讨论了 COVID-19 治疗未来发展方向的关键遗留问题。
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