Plastin 3 挽救了脊髓性肌萎缩症中的 BDNF-TrkB 信号传导。

Plastin 3 rescues BDNF-TrkB signaling in spinal muscular atrophy.

机构信息

Department of Pathology, University of California, San Francisco , San Francisco, CA, USA.

Pathology Service 113B, San Francisco Veterans Administrations Health Care System , San Francisco, CA, USA.

出版信息

J Cell Biol. 2023 Mar 6;222(3). doi: 10.1083/jcb.202301036. Epub 2023 Feb 14.

DOI:10.1083/jcb.202301036

PMID:36786833

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9960025/

Abstract

In this issue, Hennlein and colleagues (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202204113) show that F-actin-bundling protein Plastin 3 is drastically reduced in motor neurons with spinal muscular atrophy, whereas virus-mediated overexpression of Plastin 3 restores actin cytoskeleton and promotes BDNF-TrkB signaling in the growth cones of spinal motor neurons.

摘要

在本期中，Hennlein 及其同事（2023. J. Cell Biol. https://doi.org/10.1083/jcb.202204113）表明，在患有脊髓性肌萎缩症的运动神经元中，F-肌动蛋白束蛋白 Plastin 3 显著减少，而病毒介导的 Plastin 3 过表达可恢复肌动蛋白细胞骨架，并促进脊髓运动神经元生长锥中的 BDNF-TrkB 信号传导。