细枝红千层果皮中β-三酮与单萜类化合物的杂合物。
Hybrids of β-triketone and monoterpenoids from the peels of Callistemon viminalis.
作者信息
Meng Qing-Hong, Liu Hui, Wang Kai-Bo, Ling Shan-Shan, Yan Huan, Liu Hai-Yang
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Yunnan Characteristic Plant Extraction Laboratory, Kunming 650106, China; University of Chinese Academy of Sciences, Beijing 100049, China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Yunnan Characteristic Plant Extraction Laboratory, Kunming 650106, China.
出版信息
Fitoterapia. 2023 Apr;166:105459. doi: 10.1016/j.fitote.2023.105459. Epub 2023 Feb 16.
Phytoconstituents of the peels of Callistemon viminalis has been investigated for the first time. As a result, two pair of diastereomers of hybrids of β-triketone and α-phellandrene, named viminalisones A-B (1-2) and viminalisones CD (3-4), and three known analogues were obtained. Their structures and absolute configurations were elucidated through a combination of the analysis of their MS data, NMR spectra, single-crystal X-ray diffraction, and their experimental and calculated electronic circular dichroism (ECD) spectra. All isolates were evaluated for their antimicrobial activities against Botrytis cinerea and Cutibacterium acnes. Meroterpenoid 7 exhibited antibacterial activity against Botrytis cinerea with a MIC value of 0.256 mg/mL.
首次对细枝红千层果皮的植物成分进行了研究。结果，获得了两对β-三酮与α-水芹烯杂合物的非对映异构体，命名为细枝红千层酮A-B（1-2）和细枝红千层酮C-D（3-4），以及三种已知类似物。通过对它们的质谱数据、核磁共振光谱、单晶X射线衍射以及其实验和计算的电子圆二色光谱（ECD）的分析，阐明了它们的结构和绝对构型。评估了所有分离物对灰葡萄孢菌和痤疮丙酸杆菌的抗菌活性。杂萜7对灰葡萄孢菌表现出抗菌活性，最低抑菌浓度（MIC）值为0.256mg/mL。
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