Rajput Devyani, Singh Mandeep, Sahu Prashant, Jain Dharmendra, Kashaw Sushil Kumar, Patil Umesh Kumar
Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya (A Central University) Sagar M.P., 470 003, India.
Mini Rev Med Chem. 2023;23(21):2053-2072. doi: 10.2174/1389557523666230222124438.
Nanogels have gotten much attention as nanoscopic drug carriers, especially for delivering bioactive mediators to specific sites or at certain times. The versatility of polymer systems and the ease with which their physicochemical properties can be changed have resulted in versatile nano gel formulations. Nanogels offer exceptional stability, drug-loading capacity, biological consistency, strong penetration ability, and the ability to respond to environmental stimuli. Nanogels have shown great promise in various sectors, including gene delivery, chemotherapeutic medication delivery, diagnostics, organ targeting, and many more. This review focuses on various types of nanogels, preparation methods, including drug loading methods, various modes of biodegradation mechanisms, and primary mechanisms of drug release from nanogels. The article also focuses on the historical data for herb-related nanogels that are used to treat various disorders with great patient compliance, delivery rate, and efficacy.
纳米凝胶作为纳米级药物载体备受关注,尤其是用于在特定部位或特定时间递送生物活性介质。聚合物体系的多功能性以及其物理化学性质易于改变的特点,导致了多种纳米凝胶制剂的出现。纳米凝胶具有出色的稳定性、载药能力、生物相容性、强渗透能力以及对环境刺激的响应能力。纳米凝胶在各个领域都显示出了巨大的潜力,包括基因递送、化疗药物递送、诊断、器官靶向等。本综述重点介绍了各种类型的纳米凝胶、制备方法(包括载药方法)、各种生物降解机制模式以及纳米凝胶药物释放的主要机制。本文还重点介绍了与草药相关的纳米凝胶的历史数据,这些纳米凝胶用于治疗各种疾病,具有很高的患者依从性、递送率和疗效。