Maqbool M A, Gangadhara Somayaji K S, Nayana V G
Department of Otorhinolaryngology, Yenepoya medical college Deralakatte, Mangalore Dakshina Kannada, Mangalore Mangalore, Karnataka India.
Indian J Otolaryngol Head Neck Surg. 2023 Feb 14;75(3):1-6. doi: 10.1007/s12070-022-03220-z.
The aim of this study was to assess and compare the level of serum vitamin-D in participants affected with recurrent upper respiratory tract infections and in healthy population and to know whether vitamin-D deficiency is factor contributing to recurrent upper respiratory tract infections (URTI).
A case control study was conducted on 52 subjects with recurrent URTI and 52 controls. Frequency and severity of infections in the previous 6 months were assessed and documented among the case group. Vitamin D level was assessed in all the participants among case and control group and statistical analysis was done.
Mean serum vitamin D was 10.67 ± 3.58 ng/mL in the study group and 20.10 ± 7.73 ng/mL in the control group, the difference in value was statistically significant. None of the study group participants belonged to vitamin D sufficient group, and majority (98%) were in vitamin D deficient, except for 2% who were in insufficient group. In the control group, 10%,29%,61% were in sufficient, insufficient and deficient group respectively. Mean serum vitamin D was not significantly associated with severity and type of infection.
Significant number of participants in both study and control had serum vitamin D deficiency. This study also observed that a significant number of participants with recurrent URTI had serum vitamin D deficiency than the control group which suggest that hypovitaminosis D is a factor contributing to recurrent URTI.
The online version contains supplementary material available at 10.1007/s12070-022-03220-z.
本研究旨在评估和比较复发性上呼吸道感染患者与健康人群的血清维生素D水平，并了解维生素D缺乏是否是导致复发性上呼吸道感染（URTI）的因素。
对52例复发性URTI患者和52例对照进行病例对照研究。评估并记录病例组前6个月感染的频率和严重程度。对病例组和对照组的所有参与者进行维生素D水平评估并进行统计分析。
研究组的平均血清维生素D为10.67±3.58 ng/mL，对照组为20.10±7.73 ng/mL，差异具有统计学意义。研究组中没有参与者属于维生素D充足组，大多数（98%）为维生素D缺乏，只有2%为不足组。对照组中，分别有10%、29%、61%为充足、不足和缺乏组。平均血清维生素D与感染的严重程度和类型无显著相关性。
研究组和对照组中均有相当数量的参与者存在血清维生素D缺乏。本研究还观察到，复发性URTI患者中血清维生素D缺乏的人数显著多于对照组，这表明维生素D缺乏是导致复发性URTI的一个因素。
在线版本包含可在10.1007/s12070-022-03220-z获取的补充材料。
