美国海军舰艇上新冠疫情的血清流行病学调查

Seroepidemiologic Investigation of a COVID-19 Outbreak Aboard a U.S. Navy Ship.

作者信息

Legendre Brian W, Boltz Jessamyn, Riegodedios Asha Jindal, Brown Amy M, Kaplan Michael R, Feinberg Jeffrey H, Sullivan Andrew J, Dawn M Whiting, Luse Tina M, Glasheen Christine E, Poitras Beth T, Hollis Ewell, Myers Christopher

机构信息

Naval Hospital Bremerton.

Naval Health Research Center.

出版信息

MSMR. 2022 Dec 31;29(12):2-10.

PMID:36821705

Abstract

The crew of USS Kidd experienced a COVID-19 outbreak identified in April 2020. This is the earliest documented COVID-19 study with RT-PCR, serology, and pre-exposure test data on the entirety of the exposed population (n=333). Case definitions included 121 confirmed (36.3% of crewmembers) and 18 probable (5.4% of crewmembers) based on laboratory diagnostic test results. At the time of testing positive, 62 (44.6%) cases reported no symptoms. Hispanic ethnicity (AOR: 2.71, CI: 1.40-5.25) and non-smoker status (AOR: 2.28, CI: 1.26-4.12) were identified as statistically significant risk factors. This study highlights the value of rapid, onboard diagnostic testing to quickly identify an outbreak and enumerate cases, as well as the serological testing to flag potential cases missed with standard viral case identification methodologies.

摘要

“基德号”驱逐舰全体船员在2020年4月经历了一次新冠病毒疫情爆发。这是最早有记录的对全体暴露人群（n = 333）进行逆转录聚合酶链反应（RT-PCR）、血清学检测及暴露前检测数据的新冠病毒研究。根据实验室诊断检测结果，病例定义包括121例确诊病例（占船员的36.3%）和18例疑似病例（占船员的5.4%）。在检测呈阳性时，62例（44.6%）病例报告无症状。西班牙裔种族（比值比：2.71，置信区间：1.40 - 5.25）和非吸烟者状态（比值比：2.28，置信区间：1.26 - 4.12）被确定为具有统计学意义的风险因素。本研究强调了快速的船上诊断检测对于快速识别疫情和统计病例数量的价值，以及血清学检测对于标记标准病毒病例识别方法遗漏的潜在病例的价值。