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三阴性乳腺癌细胞衍生的细胞外囊泡赋予的耐药性的治疗意义

Therapeutic Implications of the Drug Resistance Conferred by Extracellular Vesicles Derived from Triple-Negative Breast Cancer Cells.

作者信息

Yi Yong Weon

机构信息

Department of Biochemistry, College of Medicine, Dankook University, Cheonan-si 31116, Chungcheongnam-do, Republic of Korea.

出版信息

Int J Mol Sci. 2023 Feb 12;24(4):3704. doi: 10.3390/ijms24043704.

DOI:10.3390/ijms24043704
PMID:36835116
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9960576/
Abstract

Anticancer drug resistance is a significant impediment in current cancer treatment. Extracellular vesicles (EVs) derived from cancer cells were recently acknowledged as a critical mechanism of drug resistance, tumor progression, and metastasis. EVs are enveloped vesicles comprising a lipid bilayer that transfers various cargo, including proteins, nucleic acids, lipids, and metabolites, from an originating cell to a recipient cell. Investigating the mechanisms whereby EVs confer drug resistance is still in the early stages. In this review, I analyze the roles of EVs derived from triple-negative breast cancer cells (TNBC-EVs) in anticancer drug resistance and discuss strategies to overcome TNBC-EV-mediated drug resistance.

摘要

抗癌药物耐药性是当前癌症治疗中的一个重大障碍。最近，源自癌细胞的细胞外囊泡（EVs）被认为是耐药性、肿瘤进展和转移的关键机制。EVs是被膜囊泡，由脂质双层组成，可将包括蛋白质、核酸、脂质和代谢物在内的各种货物从起源细胞转移到受体细胞。研究EVs赋予耐药性的机制仍处于早期阶段。在这篇综述中，我分析了三阴性乳腺癌细胞来源的EVs（TNBC-EVs）在抗癌药物耐药性中的作用，并讨论了克服TNBC-EV介导的耐药性的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb6a/9960576/6fe7b658ef34/ijms-24-03704-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb6a/9960576/d05d452c8187/ijms-24-03704-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb6a/9960576/6fe7b658ef34/ijms-24-03704-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb6a/9960576/d05d452c8187/ijms-24-03704-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb6a/9960576/6fe7b658ef34/ijms-24-03704-g002.jpg

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