Căta Adina, Ienașcu Ioana Maria Carmen, Ştefănuț Mariana Nela, Roșu Dan, Pop Oana-Raluca
National Institute of Research and Development for Electrochemistry and Condensed Matter, 144 Dr. A. P. Podeanu, 300569 Timişoara, Romania.
Department of Pharmaceutical Sciences, Faculty of Pharmacy, "Vasile Goldiș" Western University of Arad, 86 Liviu Rebreanu, 310045 Arad, Romania.
Pharmaceutics. 2023 Feb 9;15(2):589. doi: 10.3390/pharmaceutics15020589.
Amphiphilic Janus dendrimers are arrangements containing both hydrophilic and hydrophobic units, capable of forming ordered aggregates by intermolecular noncovalent interactions between the dendrimer units. Compared to conventional dendrimers, these molecular self-assemblies possess particular and effective attributes i.e., the presence of different terminal groups, essential to design new elaborated materials. The present review will focus on the pharmaceutical and biomedical application of amphiphilic Janus dendrimers. Important information for the development of novel optimized pharmaceutical formulations, such as structural classification, synthetic pathways, properties and applications, will offer the complete characterization of this type of Janus dendrimers. This work will constitute an up-to-date background for dendrimer specialists involved in designing amphiphilic Janus dendrimer-based nanomaterials for future innovations in this promising field.
两亲性Janus树枝状大分子是一种同时包含亲水性和疏水性单元的结构，能够通过树枝状大分子单元之间的分子间非共价相互作用形成有序聚集体。与传统树枝状大分子相比，这些分子自组装体具有独特而有效的特性，即存在不同的末端基团，这对于设计新型精细材料至关重要。本综述将聚焦于两亲性Janus树枝状大分子在制药和生物医学领域的应用。有关新型优化药物制剂开发的重要信息，如结构分类、合成途径、性质和应用等，将全面表征此类Janus树枝状大分子。这项工作将为从事设计基于两亲性Janus树枝状大分子的纳米材料的树枝状大分子专家提供最新的背景知识，以推动这一充满前景的领域的未来创新。
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