杆状病毒展示肽和蛋白质在医学中的应用。
Baculovirus Display of Peptides and Proteins for Medical Applications.
机构信息
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City 04510, Mexico.
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City 04510, Mexico.
出版信息
Viruses. 2023 Feb 1;15(2):411. doi: 10.3390/v15020411.
Baculoviridae is a large family of arthropod-infective viruses. Recombinant baculoviruses have many applications, the best known is as a system for large scale protein production in combination with insect cell cultures. More recently recombinant baculoviruses have been utilized for the display of proteins of interest with applications in medicine. In the present review we analyze the different strategies for the display of proteins and peptides on the surface of recombinant baculoviruses and provide some examples of the different proteins displayed. We analyze briefly the commercially available systems for recombinant baculovirus production and display and discuss the future of this emerging and powerful technology.
杆状病毒科是一类感染节肢动物的大型病毒家族。重组杆状病毒有许多应用，其中最著名的是与昆虫细胞培养相结合的大规模蛋白质生产系统。最近，重组杆状病毒已被用于表达具有医学应用的感兴趣的蛋白质。在本综述中，我们分析了在重组杆状病毒表面展示蛋白质和肽的不同策略，并提供了不同展示蛋白的一些实例。我们简要分析了可用于重组杆状病毒生产和展示的商业系统，并讨论了这项新兴强大技术的未来。
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