2型糖尿病患者的血清可体松水平及其与非酒精性脂肪性肝病的关系。
Serum Cortistatin Level in Type 2 Diabetes Mellitus and Its Relationship with Nonalcoholic Fatty Liver Disease.
作者信息
Sun Tiantian, Wang Chang, Huo Lijing, Wang Yichao, Liu Ke, Wei Changmei, Zhao Hang, Chen Shuchun, Ren Luping
机构信息
Department of Endocrinology, Hebei General Hospital, Shijiazhuang, People's Republic of China.
North China University of Science and Technology, Tangshan, People's Republic of China.
出版信息
Int J Gen Med. 2023 Feb 21;16:631-639. doi: 10.2147/IJGM.S396315. eCollection 2023.
PURPOSE
To evaluate serum cortistatin (CST) levels in type 2 diabetes mellitus (T2DM) patients with or without non-alcoholic fatty liver disease (NAFLD) and to examine the relationship between CST and NAFLD.
METHODS
A total of 90 T2DM patients, which included 56 NAFLD patients (referred to as DM+NAFLD group) and 34 patients without NAFLD (DM-only group), and 83 non-diabetes individuals that included 39 NAFLD patients (NAFLD-only group) and 44 without NAFLD that acted as the normal-control group (NC group). The differences in the serum CST levels between the groups were compared, and the correlations between CST and other variables were calculated by applying both correlational analysis and multiple linear regression analysis.
RESULTS
The mean serum CST levels were significantly lower in the DM+NAFLD and DM groups than in the NC group ( < 0.05). In addition, the CST levels were lower in the DM group relative to that in the NAFLD group ( < 0.05). However, no statistical difference was noted in the serum CST between diabetic patients with and without NAFLD ( > 0.05). Similarly, in the non-diabetic group, the serum CST level was not significantly different between individuals with and without NAFLD ( > 0.05). Furthermore, the serum CST levels were negatively associated with the levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG), homeostasis model assessment-insulin resistance (HOMA-IR), and insulin cell function index (HOMA-β). Conversely, the serum CST levels were positively associated with high-density lipoprotein cholesterol (HDL-C). The data obtained through multiple linear regression implied that LDL-C and HOMA-β, but not HOMA-IR, were closely related to serum CST levels.
CONCLUSION
T2DM was related to decreased serum CST. However, serum CST was correlated with HOMA-β in T2DM patients, while HOMA-IR was not. There was no correlation between CST and NAFLD.
目的
评估有无非酒精性脂肪性肝病（NAFLD）的2型糖尿病（T2DM）患者的血清可体松（CST）水平，并研究CST与NAFLD之间的关系。
方法
共纳入90例T2DM患者，其中56例患有NAFLD（称为DM+NAFLD组），34例无NAFLD（仅DM组）；以及83例非糖尿病个体，其中39例患有NAFLD（仅NAFLD组），44例无NAFLD作为正常对照组（NC组）。比较各组血清CST水平的差异，并通过相关分析和多元线性回归分析计算CST与其他变量之间的相关性。
结果
DM+NAFLD组和DM组的平均血清CST水平显著低于NC组（P<0.05）。此外，DM组的CST水平低于NAFLD组（P<0.05）。然而，有无NAFLD的糖尿病患者血清CST无统计学差异（P>0.05）。同样，在非糖尿病组中，有无NAFLD的个体血清CST水平无显著差异（P>0.05）。此外，血清CST水平与总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、空腹血糖（FPG）、稳态模型评估胰岛素抵抗（HOMA-IR）和胰岛素细胞功能指数（HOMA-β）水平呈负相关。相反，血清CST水平与高密度脂蛋白胆固醇（HDL-C）呈正相关。多元线性回归数据表明，LDL-C和HOMA-β而非HOMA-IR与血清CST水平密切相关。
结论
T2DM与血清CST降低有关。然而，T2DM患者血清CST与HOMA-β相关，而与HOMA-IR无关。CST与NAFLD之间无相关性。
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