臭氧对小鼠L929成纤维细胞的毒性作用。对DNA的损伤。
Toxic effects of ozone on murine L929 fibroblasts. Damage to DNA.
作者信息
Van der Zee J, Van Beek E, Dubbelman T M, Van Steveninck J
机构信息
Department of Medical Biochemistry, Sylvius Laboratories, Leiden, The Netherlands.
出版信息
Biochem J. 1987 Oct 1;247(1):69-72. doi: 10.1042/bj2470069.
Abstract
Damage to DNA caused by exposure of L929 fibroblasts to ozone was reflected by the generation of strand breaks, DNA inter-strand cross-links and DNA-protein cross-links. Addition of propan-2-ol, a hydroxyl radical scavenger, did not affect the formation of strand breaks. In model experiments it appeared that both purines and pyrimidines were involved in DNA inter-strand and DNA-protein cross-links.
摘要
L929成纤维细胞暴露于臭氧所导致的DNA损伤表现为链断裂、DNA链间交联和DNA-蛋白质交联的产生。添加羟基自由基清除剂丙-2-醇并不影响链断裂的形成。在模型实验中，似乎嘌呤和嘧啶都参与了DNA链间和DNA-蛋白质交联。
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