Hamed Samira M, Sakr Masarra M, El-Housseiny Ghadir S, Wasfi Reham, Aboshanab Khaled M
Department of Microbiology & Immunology, Faculty of Pharmacy, October University for Modern Sciences & Arts (MSA), Giza, 12451, Egypt.
Department of Microbiology & Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Future Sci OA. 2023 Feb;16(3-06):FSO832. doi: 10.2144/fsoa-2022-0048. Epub 2023 Mar 6.
The understanding of any disease calls for studying specific biological structures called epitopes. One important tool recently drawing attention and proving efficiency in both diagnosis and vaccine development is epitope mapping. Several techniques have been developed with the urge to provide precise epitope mapping for use in designing sensitive diagnostic tools and developing rpitope-based vaccines (EBVs) as well as therapeutics. In this review, we will discuss the state of the art in epitope mapping with a special emphasis on accomplishments and opportunities in combating COVID-19. These comprise SARS-CoV-2 variant analysis versus the currently available immune-based diagnostic tools and vaccines, immunological profile-based patient stratification, and finally, exploring novel epitope targets for potential prophylactic, therapeutic or diagnostic agents for COVID-19.
对任何疾病的理解都需要研究称为表位的特定生物结构。表位作图是一种最近引起关注并在诊断和疫苗开发中都证明有效的重要工具。为了提供精确的表位作图以用于设计灵敏的诊断工具、开发基于表位的疫苗（EBV）以及治疗方法，已经开发了几种技术。在这篇综述中，我们将讨论表位作图的最新进展，特别强调在抗击 COVID-19 方面的成就和机遇。这些包括 SARS-CoV-2 变体分析与当前可用的基于免疫的诊断工具和疫苗、基于免疫特征的患者分层，以及最后探索 COVID-19 潜在预防、治疗或诊断剂的新型表位靶点。
