子宫内膜异位症是否会影响白细胞介素6和抗苗勒管激素在卵泡液中的成分？一项病例对照研究。
Does Endometriosis Impact the Composition of Follicular Fluid in IL6 and AMH? A Case-Control Study.
作者信息
Kacem-Berjeb Khadija, Braham Marouen, Massoud Cyrine Ben, Hannachi Hela, Hamdoun Manel, Chtourou Sana, Debbabi Linda, Bouyahia Maha, Fadhlaoui Anis, Zhioua Fethi, Feki Anis, Chakroun Nozha, Bahri Olfa
机构信息
Department of Reproductive Biology and Cytogenetics, Aziza Othmana Hospital, University of Tunis, Tunis 1008, Tunisia.
Research Laboratory LR16SP01 "Infertility and Oncofertility", Tunis 1008, Tunisia.
出版信息
J Clin Med. 2023 Feb 24;12(5):1829. doi: 10.3390/jcm12051829.
OBJECTIVE
The aim of this study was to compare follicular liquid levels of IL6 and AMH in women with and without endometriosis and to evaluate their potential impact on ICSI outcomes.
MATERIALS AND METHODS
It is a prospective case-control study conducted on 25 women with proven endometriosis and 50 patients diagnosed with other causes of infertility. All these patients were candidates for ICSI cycles. Their follicular fluid was collected at the time of oocyte retrieval and used to evaluate IL-6 and AMH titers by electro-chemiluminescent immunoassay (Cobas e411-Roche).
RESULTS
The IL-6 levels in follicular fluid were higher in the endometriosis group than in the control group (152.3 vs. 19.9 pg/mL; = 0.02). The median level for AMH was 2.2 ± 1.88 ng/mL with no statistical difference between the two groups (2.2 vs. 2.7 ng/mL, = 0.41). No significant correlation between the follicular IL6 and AMH levels was observed.
CONCLUSIONS
The oocyte quality seems to be preserved in patients with endometriosis with the adequate response to ovarian stimulation. High levels of follicular IL6 are in accordance with the inflammatory phenomenon of the disease; however, this increase has no impact on ICSI outcomes.
目的
本研究旨在比较患有和未患有子宫内膜异位症的女性卵泡液中白细胞介素6（IL6）和抗苗勒管激素（AMH）的水平，并评估它们对卵胞浆内单精子注射（ICSI）结局的潜在影响。
材料与方法
这是一项前瞻性病例对照研究，对25例经证实患有子宫内膜异位症的女性和50例被诊断为其他不孕原因的患者进行。所有这些患者均为ICSI周期的候选者。在取卵时收集她们的卵泡液，并通过电化学发光免疫分析法（Cobas e411 - 罗氏公司）用于评估IL - 6和AMH滴度。
结果
子宫内膜异位症组卵泡液中的IL - 6水平高于对照组（152.3对19.9 pg/mL；P = 0.02）。AMH的中位水平为2.2±1.88 ng/mL，两组之间无统计学差异（2.2对2.7 ng/mL，P = 0.41）。未观察到卵泡液中IL6和AMH水平之间存在显著相关性。
结论
对于卵巢刺激有充分反应的子宫内膜异位症患者，其卵母细胞质量似乎得以保留。卵泡液中高水平的IL6与该疾病的炎症现象相符；然而，这种升高对ICSI结局没有影响。
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