使用从头设计的蛋白质进行蛋白质电路设计。

Protein circuit design using de novo proteins.

机构信息

School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.

出版信息

Trends Biotechnol. 2023 May;41(5):593-594. doi: 10.1016/j.tibtech.2023.02.011. Epub 2023 Mar 10.

DOI:10.1016/j.tibtech.2023.02.011

PMID:36906493

Abstract

Protein-based biological circuits enable customized control of cellular functions, and de novo protein design enables circuit functionalities that are not possible by repurposing natural proteins. Here, I highlight recent progress in protein circuit design, including CHOMP, developed by Gao et al., and SPOC, developed by Fink et al.

摘要

基于蛋白质的生物电路能够实现对细胞功能的定制化控制，而从头设计蛋白质则能够实现通过重新利用天然蛋白质无法实现的电路功能。在此，我将重点介绍蛋白质电路设计方面的最新进展，包括 Gao 等人开发的 CHOMP 和 Fink 等人开发的 SPOC。