儿童、青少年和青年实体器官移植后淋巴组织增生性疾病的诊断和治疗。
Diagnosis and management of post-transplant lymphoproliferative disease following solid organ transplantation in children, adolescents, and young adults.
机构信息
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue MLC 7018, Cincinnati, OH, 45229, USA.
Center for Cancer and Blood Disorder, Children's National Hospital, Washington, DC, USA; Center for Cancer and Immunology Research, Children's National Hospital, 111 Michigan Ave NW, Washington, DC, 20010, USA.
出版信息
Best Pract Res Clin Haematol. 2023 Mar;36(1):101446. doi: 10.1016/j.beha.2023.101446. Epub 2023 Feb 3.
Post-transplant Lymphoproliferative Disease (PTLD) remains a major complication of solid organ transplantation (SOT) in pediatric patients. The majority are Epstein-Barr Virus (EBV) driven CD20 B-cell proliferations responsive to reduction to immunosuppression and anti-CD20 directed immunotherapy. This review focusses on the epidemiology, role of EBV, clinical presentation, current treatment strategies, adoptive immunotherapy and future research in EBV + PTLD in pediatric patients.
移植后淋巴组织增生性疾病 (PTLD) 仍然是儿科实体器官移植 (SOT) 的主要并发症。大多数是由 Epstein-Barr 病毒 (EBV) 驱动的 CD20 B 细胞增殖，对减少免疫抑制和抗 CD20 导向的免疫治疗有反应。这篇综述重点介绍了 EBV+PTLD 在儿科患者中的流行病学、EBV 的作用、临床表现、当前治疗策略、过继免疫治疗和未来研究。
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