巴西和美国产近平滑念珠菌复合体的全基因组测序：遗传多样性和抗真菌药敏性。
Whole-genome sequencing of Candida haemulonii species complex from Brazil and the United States: Genetic diversity and antifungal susceptibility.
机构信息
Programa de Pós-graduação em Doenças Infecciosas e Parasitárias, Universidade Federal do Mato Grosso do Sul, Mato Grosso do Sul, MS, Brazil.
Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
出版信息
Med Mycol. 2023 Apr 3;61(4). doi: 10.1093/mmy/myad030.
Candida haemulonii complex species can be multidrug-resistant and cause infections such as candidemia. This study determined the genetic relationship between isolates from Brazil and the United States through whole-genome sequencing and performed antifungal susceptibility testing to investigate drug resistance. Contrary to what is widely described, most isolates were susceptible to azoles. However, an atypical susceptibility profile was found in 50% of Candida pseudohaemulonii strains, including resistance to the three echinocandins. Isolates from both countries formed distinct clusters with wide genetic diversity. Isolates from three hospitals in Brazil were clonal and involved in candidemia cases, pointing to the importance of improving hospital infection control measures and molecular identification.
半滑舌鳎复合种可能具有多药耐药性，并导致念珠菌血症等感染。本研究通过全基因组测序确定了来自巴西和美国的分离株之间的遗传关系，并进行了抗真菌药敏试验以研究耐药性。与广泛描述的情况相反，大多数分离株对唑类药物敏感。然而，在 50%的假半滑舌鳎念珠菌菌株中发现了一种非典型的药敏谱，包括对三种棘白菌素的耐药性。来自两国的分离株形成了具有广泛遗传多样性的不同聚类。来自巴西三家医院的分离株是克隆的，并与念珠菌血症病例有关，这表明有必要加强医院感染控制措施和分子鉴定。
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