Chantaraprateep P, Thibier M
Andrologia. 1979 Jan;11(1):25-32. doi: 10.1111/j.1439-0272.1979.tb02154.x.
LH and testosterone responses to gonadoliberin (LRH) were studied after previous dexamethasone and testosterone propionate combined treatment (treated group) compared with a single dexamethasone previous treatment (control group) in 12 Montbéliarde bulls aged 15 months. This experiment was performed on two occaisions 6 months apart according to the same schedule. They included each time 6 bulls, treated with intramuscular injections of 400 mg testosterone propionate and 6 hours later 0.25 mg gonadoliberin together with the other 3 bulls. Testosterone propionate did not influence the mean LH response to gonadoliberin although mean testosterone levels before gonadoliberin injection was very low in the controls. These data suggest that (1) the previously reported depressing effect of dexamethasone on LH is not mediated by the low peripheral testosterone level and (2) under the conditions of this study, there is no short term effect of testosterone at the pituitary level.
在12头15月龄的蒙贝利亚尔公牛中，研究了先前地塞米松和丙酸睾酮联合治疗后（治疗组）与单次地塞米松先前治疗后（对照组）促性腺激素释放激素（LRH）对促黄体生成素（LH）和睾酮的反应。本实验按照相同方案在两次间隔6个月的时间进行。每次实验包括6头公牛，肌肉注射400mg丙酸睾酮，6小时后注射0.25mg促性腺激素释放激素，另外3头公牛作为对照。尽管在对照组中，促性腺激素释放激素注射前的平均睾酮水平非常低，但丙酸睾酮并未影响促性腺激素释放激素对促黄体生成素的平均反应。这些数据表明：（1）先前报道的地塞米松对促黄体生成素的抑制作用不是由外周低睾酮水平介导的；（2）在本研究条件下，睾酮在垂体水平没有短期作用。
