Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Br J Psychiatry. 2023 May;222(5):204-211. doi: 10.1192/bjp.2023.8.
Mother and father depression symptoms often co-occur, and together can have a substantial impact on child emotional well-being. Little is understood about symptom-level mechanisms underlying the co-occurrence of depression symptoms within families.
The objective was to use network analysis to examine depression symptoms in mothers and fathers after having a baby, and emotional symptoms in children in early adolescence.
We examined data from 4492 mother-father-child trios taken from a prospective, population-based cohort in the UK. Symptoms were examined using two unregularised partial correlation network models. The initial model was used to examine the pattern of associations, i.e. the overall network structure, for mother and father depression symptoms, and then to identify bridge symptoms that reinforce depression symptoms between parents during offspring infancy. The second model examined associations between the parent symptom network, including bridge symptoms, with later child emotional difficulties.
The study included 4492 mother-father-child trios; 2204 (49.1%) children were female. Bridge symptoms reinforcing mother and father depression symptoms were feeling guilty and self-harm ideation. For mothers, the bridge symptom of feeling guilty, and symptoms of anhedonia, panic and sadness were highly connected with child emotional difficulties. For fathers, the symptom of feeling overwhelmed associated with child emotional difficulties. Guilt and anhedonia in fathers appeared to indirectly associate with child emotional difficulties through the same symptom in mothers.
Our findings suggest that specific symptom cascades are central for co-occurring depression in parents and increased vulnerability in children, providing potential therapeutic targets.
母亲和父亲的抑郁症状常常同时出现,这对孩子的情绪健康会产生重大影响。对于家庭中抑郁症状同时出现的症状层面机制,我们知之甚少。
本研究旨在使用网络分析来考察婴儿出生后父母的抑郁症状以及青少年早期儿童的情绪症状。
我们对来自英国一项前瞻性、基于人群的队列研究中的 4492 对母婴-儿童三胞胎数据进行了分析。使用两个非正则化部分相关网络模型来检查症状。初始模型用于检查母亲和父亲抑郁症状的关联模式,即整体网络结构,然后识别在后代婴儿期加强父母之间抑郁症状的桥梁症状。第二个模型考察了包括桥梁症状在内的父母症状网络与后期儿童情绪困难之间的关联。
本研究共纳入了 4492 对母婴-儿童三胞胎,其中 2204 名(49.1%)儿童为女性。加强母亲和父亲抑郁症状的桥梁症状为内疚感和自杀意念。对于母亲来说,内疚感和快感缺失、惊恐和悲伤等症状与儿童的情绪困难高度相关。对于父亲来说,感到不知所措的症状与儿童的情绪困难有关。父亲的内疚感和快感缺失似乎通过母亲的相同症状间接地与儿童的情绪困难有关。
我们的研究结果表明,特定的症状级联是父母共病抑郁和儿童易感性增加的核心,为潜在的治疗靶点提供了依据。