关于糖尿病前期与衰老的思考。

Perspectives on Prediabetes and Aging.

机构信息

Division of Endocrinology, Department of Internal Medicine, College of Medicine, King Saud University, Riyadh, Central Region, 12372, Saudi Arabia; Division of Endocrinology, Diabetes & Metabolism, The Johns Hopkins University, 1830 East Monument Street, Baltimore, MD 21287, USA.

Division of Endocrinology, Department of Internal Medicine, College of Medicine, King Saud University, Riyadh, Central Region, 12372, Saudi Arabia.

出版信息

Endocrinol Metab Clin North Am. 2023 Jun;52(2):377-388. doi: 10.1016/j.ecl.2022.10.011. Epub 2023 Feb 16.

DOI:10.1016/j.ecl.2022.10.011

PMID:36948785

Abstract

Diabetes prevention programs (DPPs) have been shown to effectively delay, and sometimes prevent, the progression from prediabetes to diabetes; however, labeling someone with prediabetes comes with potential negative psychological, financial, and self-perception consequences. Many older adults with prediabetes nowadays have a relatively "low-risk" form of prediabetes that rarely progresses to diabetes and may regress to normoglycemia. In this article, we review the impact of aging on glucose metabolism and provide a holistic approach to cases of prediabetes in older adults that maximizes the benefit-risk balance of interventions aimed at addressing prediabetes.

摘要

糖尿病预防计划（DPP）已被证明可有效延缓，甚至有时可预防前驱糖尿病向糖尿病的进展；然而，将某人标记为前驱糖尿病可能会带来潜在的负面心理、经济和自我认知后果。如今，许多患有前驱糖尿病的老年人都存在一种相对“低危”的前驱糖尿病形式，这种前驱糖尿病很少进展为糖尿病，而且可能会恢复到正常血糖水平。在本文中，我们回顾了衰老对葡萄糖代谢的影响，并为老年人的前驱糖尿病病例提供了一种整体方法，最大限度地平衡了针对前驱糖尿病干预措施的获益-风险比。