Andrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA 91125, USA.
Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Sci Adv. 2023 Mar 24;9(12):eadf7388. doi: 10.1126/sciadv.adf7388.
Chronic nonhealing wounds are one of the major and rapidly growing clinical complications all over the world. Current therapies frequently require emergent surgical interventions, while abuse and misapplication of therapeutic drugs often lead to an increased morbidity and mortality rate. Here, we introduce a wearable bioelectronic system that wirelessly and continuously monitors the physiological conditions of the wound bed via a custom-developed multiplexed multimodal electrochemical biosensor array and performs noninvasive combination therapy through controlled anti-inflammatory antimicrobial treatment and electrically stimulated tissue regeneration. The wearable patch is fully biocompatible, mechanically flexible, stretchable, and can conformally adhere to the skin wound throughout the entire healing process. Real-time metabolic and inflammatory monitoring in a series of preclinical in vivo experiments showed high accuracy and electrochemical stability of the wearable patch for multiplexed spatial and temporal wound biomarker analysis. The combination therapy enabled substantially accelerated cutaneous chronic wound healing in a rodent model.
慢性难愈性创面是全世界范围内主要且快速增长的临床并发症之一。目前的治疗方法经常需要紧急手术干预，而治疗药物的滥用和误用常常导致发病率和死亡率的增加。在这里，我们介绍了一种可穿戴式生物电子系统，该系统通过定制的多路复用多模态电化学生物传感器阵列无线且连续地监测创面床的生理状况，并通过非侵入性的抗炎抗菌联合治疗以及电刺激组织再生来进行治疗。该可穿戴贴片完全生物兼容，机械上具有柔韧性、可拉伸性，并且在整个愈合过程中都能与皮肤创面完全贴合。在一系列临床前体内实验中的实时代谢和炎症监测显示，该可穿戴贴片在进行多路复用的时空创面生物标志物分析时具有高准确性和电化学稳定性。联合治疗使啮齿动物模型中的皮肤慢性创面愈合得到了显著加速。
