从L.种子中提取的精油成分及抗菌特性的综合研究
Comprehensive Study of Components and Antimicrobial Properties of Essential Oil Extracted from L. Seeds.
作者信息
Liu Changhai, Cheng Feng, Aisa Haji Akber, Maiwulanjiang Maitinuer
机构信息
Xinjiang Key Laboratory of Plant Resources and Natural Products Chemistry, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China.
College of Chemical Sciences, University of the Chinese Academy of Sciences, Beijing 100039, China.
出版信息
Antibiotics (Basel). 2023 Mar 16;12(3):591. doi: 10.3390/antibiotics12030591.
L. belongs to the family and is widely used as a vegetable, food spice, preservative, and herbal medicine. This study investigated the impact of essential oil extracted from L. seeds (CEO) on methicillin-resistant (MRSA) and its possible action mechanism. The dominant chemical components of CEO determined by GC-MS were carvone and limonene. It was observed that CEO had a considerable inhibitory effect against the growth of planktonic bacteria and biofilm in MRSA cells. Untargeted metabolomics based on GC-Q-TOF-MS was used to analyze the possible mechanism of the interaction of MRSA with CEO. It was determined that there were 63 different metabolites based on fold change values greater than 1.5 or less than 1.5, < 0.05, VIP > 1, which demonstrated amino acid metabolism in MRSA was significantly affected by CEO. In conclusion, CEO has a potent antimicrobial property and has promising potential for use in food and drugs.
L. 属于该科，被广泛用作蔬菜、食品香料、防腐剂和草药。本研究调查了从L. 种子中提取的精油（CEO）对耐甲氧西林金黄色葡萄球菌（MRSA）的影响及其可能的作用机制。通过气相色谱 - 质谱联用（GC - MS）测定的CEO的主要化学成分是香芹酮和柠檬烯。观察到CEO对MRSA细胞中浮游细菌的生长和生物膜具有相当大的抑制作用。基于气相色谱 - 四极杆 - 飞行时间质谱（GC - Q - TOF - MS）的非靶向代谢组学用于分析MRSA与CEO相互作用的可能机制。根据倍数变化值大于1.5或小于1.5、P < 0.05、变量重要性投影（VIP）> 1确定有63种不同的代谢物，这表明MRSA中的氨基酸代谢受到CEO的显著影响。总之，CEO具有强大的抗菌特性，在食品和药物应用方面具有广阔的前景。
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