Syroeshkin Anton V, Petrov Gleb V, Taranov Viktor V, Pleteneva Tatiana V, Koldina Alena M, Gaydashev Ivan A, Kolyabina Ekaterina S, Galkina Daria A, Sorokina Ekaterina V, Uspenskaya Elena V, Kazimova Ilaha V, Morozova Mariya A, Lebedeva Varvara V, Cherepushkin Stanislav A, Tarabrina Irina V, Syroeshkin Sergey A, Tertyshnikov Alexander V, Grebennikova Tatiana V
Department of Pharmaceutical and Toxicological Chemistry, Medical Institute, RUDN University, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.
Department of Environmental Instrumentation, National Technical University of Ukraine "Igor Sikorsky Kyiv Polytechnic Institute", 37, Prosp. Peremohy, 03056 Kyiv, Ukraine.
Pharmaceutics. 2023 Mar 16;15(3):966. doi: 10.3390/pharmaceutics15030966.
It has recently been shown that the titer of the SARS-CoV-2 virus decreases in a cell culture when the cell suspension is irradiated with electromagnetic waves at a frequency of 95 GHz. We assumed that a frequency range in the gigahertz and sub-terahertz ranges was one of the key aspects in the "tuning" of flickering dipoles in the dispersion interaction process of the surfaces of supramolecular structures. To verify this assumption, the intrinsic thermal radio emission in the gigahertz range of the following nanoparticles was studied: virus-like particles (VLP) of SARS-CoV-2 and rotavirus A, monoclonal antibodies to various RBD epitopes of SARS-CoV-2, interferon-α, antibodies to interferon-γ, humic-fulvic acids, and silver proteinate. At 37 °C or when activated by light with λ = 412 nm, these particles all demonstrated an increased (by two orders of magnitude compared to the background) level of electromagnetic radiation in the microwave range. The thermal radio emission flux density specifically depended on the type of nanoparticles, their concentration, and the method of their activation. The thermal radio emission flux density was capable of reaching 20 μW/(m sr). The thermal radio emission significantly exceeded the background only for nanoparticles with a complex surface shape (nonconvex polyhedra), while the thermal radio emission from spherical nanoparticles (latex spheres, serum albumin, and micelles) did not differ from the background. The spectral range of the emission apparently exceeded the frequencies of the Ka band (above 30 GHz). It was assumed that the complex shape of the nanoparticles contributed to the formation of temporary dipoles which, at a distance of up to 100 nm and due to the formation of an ultrahigh strength field, led to the formation of plasma-like surface regions that acted as emitters in the millimeter range. Such a mechanism makes it possible to explain many phenomena of the biological activity of nanoparticles, including the antibacterial properties of surfaces.
最近有研究表明，当细胞悬液受到95吉赫兹频率的电磁波照射时，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒的滴度在细胞培养中会降低。我们假设，吉赫兹和亚太赫兹范围内的频率范围是超分子结构表面色散相互作用过程中闪烁偶极子“调谐”的关键因素之一。为了验证这一假设，研究了以下纳米颗粒在吉赫兹范围内的固有热辐射：SARS-CoV-2和轮状病毒A的病毒样颗粒（VLP）、针对SARS-CoV-2各种受体结合域（RBD）表位的单克隆抗体、干扰素-α、抗干扰素-γ抗体、腐殖-富里酸和蛋白银。在37℃或用波长λ = 412nm的光激活时，这些颗粒在微波范围内均表现出电磁辐射水平升高（与背景相比提高了两个数量级）。热辐射通量密度具体取决于纳米颗粒的类型、浓度及其激活方法。热辐射通量密度能够达到20微瓦/（米·球面度）。仅对于具有复杂表面形状（非凸多面体）的纳米颗粒，热辐射才显著超过背景，而球形纳米颗粒（乳胶球、血清白蛋白和胶束）的热辐射与背景无差异。辐射的光谱范围显然超过了Ka波段（高于30吉赫兹）的频率。据推测，纳米颗粒的复杂形状有助于形成临时偶极子，这些偶极子在高达100纳米的距离处，由于形成超高强度场，导致形成类似等离子体的表面区域，这些区域在毫米范围内充当发射器。这样一种机制能够解释纳米颗粒生物活性的许多现象，包括表面的抗菌特性。
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