Wu Yunwen, Zhang Nannan, Wang Lu, Zhang Qingfeng, Yuan Qing, Wang Xin, Xie Huifen, Lv Jiamu, Li Jinen
Department of Otorhinolaryngology Head and Neck Surgery,Shenzhen University General Hospital,Shenzhen University Clinical Medical Academy,Shenzhen University,Shenzhen,518055,China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2023 Apr;37(4):297-301. doi: 10.13201/j.issn.2096-7993.2023.04.012.
To investigate the changes of inflammation and immune function in children with chronic tonsillitis after tonsillotomy. Prospectively collected 60 children with obstructive sleep apnea (OSA) diagnosed as chronic tonsillitis with adenoids and tonsillar hypertrophy from January to June 2021. Two groups were divided, the experimental group (=30) underwent bilateral partial tonsillectomy + adenoidectomy by hypothermia plasma ablation, and the control group (=30) underwent adenoidectomy by using the same hypothermia plasma ablation method. The number of tonsillitis attacks before surgery and within one year after surgery was recorded, and the serum immunoglobulin IgM, IgG, IgA, complement C3 and complement C4 levels before operation, one month and three months after operation were measured. The number of tonsillitis attacks in the experimental group and the control group at one year after surgery was lower than that before surgery(<0.05); The number of inflammatory attacks in the experimental group was (0.50±0.63) times/year, which was lower than that of (1.33±0.80) times/year in the control group. There was no significant difference in the five immunization results of the two groups at one month and three months after operation compared with before operation, and there was also no significant difference between the experimental and the control groups. Partial tonsillectomy can be applied to children with chronic tonsillitis, which can effectively reduce the number of tonsillitis attacks and has no effect on the immune function of children.
探讨扁桃体切除术后慢性扁桃体炎患儿炎症及免疫功能的变化。前瞻性收集2021年1月至6月诊断为慢性扁桃体炎伴腺样体及扁桃体肥大的60例阻塞性睡眠呼吸暂停(OSA)患儿。分为两组,实验组(n = 30)采用低温等离子消融术行双侧部分扁桃体切除术+腺样体切除术,对照组(n = 30)采用相同的低温等离子消融术行腺样体切除术。记录术前及术后1年内扁桃体炎发作次数,检测术前、术后1个月及3个月血清免疫球蛋白IgM、IgG、IgA、补体C3和补体C4水平。实验组和对照组术后1年扁桃体炎发作次数均低于术前(P<0.05);实验组炎症发作次数为(0.50±0.63)次/年,低于对照组的(1.33±0.80)次/年。两组术后1个月和3个月五项免疫指标结果与术前比较差异无统计学意义,实验组与对照组比较差异也无统计学意义。部分扁桃体切除术可应用于慢性扁桃体炎患儿,能有效减少扁桃体炎发作次数,且对患儿免疫功能无影响。