Department of Psychology, Georgetown University, Washington, DC, USA.
Department of Psychology, Washington State University, Pullman, DC, USA.
Transl Psychiatry. 2023 Mar 30;13(1):105. doi: 10.1038/s41398-023-02363-z.
Functional magnetic resonance imaging (fMRI) studies consistently indicate differences in emotion processing in youth with conduct problems. However, no prior meta-analysis has investigated emotion-specific responses associated with conduct problems. This meta-analysis aimed to generate an up-to-date assessment of socio-affective neural responding among youths with conduct problems. A systematic literature search was conducted in youths (ages 10-21) with conduct problems. Task-specific seed-based d mapping analyses examined responses to threatening images, fearful and angry facial expressions, and empathic pain stimuli from 23 fMRI studies, which included 606 youths with conduct problems and 459 comparison youths. Whole-brain analyses revealed youths with conduct problems relative to typically developing youths, when viewing angry facial expressions, had reduced activity in left supplementary motor area and superior frontal gyrus. Additional region of interest analyses of responses to negative images and fearful facial expressions showed reduced activation in right amygdala across youths with conduct problems. Youths with callous-unemotional traits also exhibited reduced activation in left fusiform gyrus, superior parietal gyrus, and middle temporal gyrus when viewing fearful facial expressions. Consistent with the behavioral profile of conduct problems, these findings suggest the most consistent dysfunction is found in regions associated with empathic responding and social learning, including the amygdala and temporal cortex. Youth with callous-unemotional traits also show reduced activation in the fusiform gyrus, consistent with reduced attention or facial processing. These findings highlight the potential role of empathic responding, social learning, and facial processing along with the associated brain regions as potential targets for interventions.
功能磁共振成像（fMRI）研究一致表明，有行为问题的年轻人在情绪处理方面存在差异。然而，以前的元分析并未研究与行为问题相关的特定情绪反应。本元分析旨在对有行为问题的年轻人的社会情感神经反应进行最新评估。对有行为问题的年轻人（年龄 10-21 岁）进行了系统的文献检索。特定任务的种子基 d 映射分析检查了来自 23 项 fMRI 研究的威胁图像、恐惧和愤怒面部表情以及共情疼痛刺激的反应，其中包括 606 名有行为问题的年轻人和 459 名对照组年轻人。全脑分析显示，与典型发育的年轻人相比，观看愤怒面部表情时，有行为问题的年轻人左补充运动区和额上回的活动减少。对负面图像和恐惧面部表情的反应的额外兴趣区域分析显示，有行为问题的年轻人的右侧杏仁核激活减少。观看恐惧面部表情时，冷酷无情特征的年轻人还表现出左侧梭状回、顶叶上回和颞中回的激活减少。这些发现与行为问题的行为特征一致，表明最一致的功能障碍发生在与共情反应和社会学习相关的区域，包括杏仁核和颞叶。冷酷无情特征的年轻人在梭状回的激活也减少，这与注意力或面部处理减少一致。这些发现强调了共情反应、社会学习和面部处理以及相关脑区作为干预潜在目标的潜在作用。
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